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Are you someone who is excited about getting in on the ground floor of a biotech company founded on a validated drug discovery platform? We are seeking passionate drug hunters to build our growing “spin-out” company – Kimia Therapeutics. Kimia is innovating drug discovery by combining Chemotype Evolution with state-of-the-art computational approaches to drug major disease pathways.

Position Summary

In this research position, you will play a leading role in applying Chemotype Evolution to identify and optimize novel drug leads for internal and partnered programs. You will design, qualify, and execute biochemical and cellular assays for high throughput drug discovery programs powered by our core platform, Chemotype Evolution. Working closely with scientists in biology and chemistry as part of a multidisciplinary team, the candidate will integrate diverse chemical and biological data to accelerate lead discovery. The ideal candidate is a team-player, motivated by novel challenges, and enthusiastically pursues creative solutions to achieve common goals.

Primary responsibilities

• Design biochemical, biophysical, and cellular assays based on literature precedents and/or experience, according to program needs
• Optimize, validate, and troubleshoot assays for robustness, sensitivity, and reproducibility to enable implementation for high-throughput screening
• Develop and implement program-specific screening cascades or triage schemes
• Run compound screening high-throughput workflows
• Monitor assay data quality and facilitate communication of data and analysis to project teams in a clear and timely manner
• Regular presentation of research progress at internal meetings and with external collaborators
• Manage, mentor and provide technical guidance to reports and other members of the team

Required experience and skills

• MS (+14 yrs) or PhD (+5 yrs) with industry experience in biochemistry, cell biology, or drug discovery
• Extensive experience conducting high throughput library screening campaigns
• Experience developing biochemical and cellular assays
• Demonstrated understanding of quality parameters in assay development and optimization
• Understanding of methods to determine mechanism of action for small molecule activators/inhibitors of enzyme activity, including covalent molecules
• Excellent communication, organization and data analysis skills

Carmot Therapeutics, Inc. is “spinning-off” its technology platform to newly-formed Kimia Therapeutics. The Chemotype Evolution platform enables rapid synthesis and screening of target-focused chemical libraries, thereby providing relevant, information-rich datasets ideally suited for machine learning. Kimia Therapeutics is building a next generation drug discovery engine by combining Chemotype Evolution with state-of-the-art computational approaches to accelerate drug discovery for challenging targets implicated in cancer and immunological disorders.

Kimia offers competitive pay, participation in our stock option plan, and comprehensive benefits.  This position is located in Berkeley, CA.  To apply, please forward your resume and contact information to careers@kimiatx.com and include “DiscoTech H09” in the subject line. Carmot and Kimia are equal opportunity employers.