Career Center

Memorial Sloan Kettering Cancer Center (MSK) is one of the world’s premier cancer centers, committed to exceptional patient care, leading-edge research, and superb educational programs. The blending of research with patient care is at the heart of everything we do. The institution is a comprehensive cancer center whose purposes are the treatment and control of cancer, the advancement of biomedical knowledge through laboratory and clinical research, and the training of scientists, physicians and other health care workers.

The Gene Editing and Screening (GES) Core Facility (https://www.mskcc.org/research-advantage/core-facilities/rnai-core)  is recruiting a senior level scientist to provide high content cell-based screening (HCS) and small molecule high throughput screening (HTS) for researchers at MSKCC and outside clients.  Arrayed small molecule and siRNA libraries, along with pooled functional genomics CRISPR-Cas9 and shRNA libraries, are offered for such screens. Core services include: assay development, performing large screens, data analysis, hit calling, confirmation and validation of hits, statistical calculations, dose response curves, drug and radiation synergies, synthetic lethality, and signaling pathway associations.

Responsibilities:

• Develop cell-based and non- cell-based assays for HCS and HTS screens
• Perform arrayed RNAi, CRISPR, and small molecule screening experiments in a high-throughput screening format
• Acquire large-scale image / screening data and perform statistical data analysis 
• Collect and enter data, assist in analyzing data, preparation of reports and manuscripts.
• Maintain and develop protocols for laboratory automation including chemical inventory
• Attend and participate in project meetings, assist in preparing and conducting experiments following established procedures or protocols, summarize results of experiments performed, and assist in interpreting the results of studies
• Assist with maintaining, testing and/or implementation of robotics and automation
• Interact with students / other laboratory members: assist with work as directed by the PI

Education and experience:

• Ph.D. in cell or molecular biology or related field required
• Extensive hands-on experience with large scale tissue culture
• Minimum of 3-5 years experience in running microscopy-based studies
• Experience in advanced image analysis (i.e. ImageJ, Zen Blue, Columbus)
• Management of laboratory robotic equipment

Technical Knowledge and Competencies:

• Experience with HCS and HTS assay development (biochemical/ cell-based) required

• Capacity to handle multiple tasks and competing demands under tight timeframes
• Ability to work under pressure, manage competing deadlines and priorities in a fast-paced research institute environment; respect project confidentiality
• Ability to summarize detailed issues in a concise and structured manner
• Ability to understand and carry out instructions; solve problems in complex situations
• Ability to interact with all levels of staff in a professional manner
• Must demonstrate excellent interpersonal and communication skills
• Excellent verbal and written communication skills required
• Capacity to exhibit adept multi-tasking and organizational skills required
• Willingness to work independently and in a collaborative team environment