Research Scientist Bioassay R&D-UICentre-Pharmaceutical Sciences
UICentre-Pharmaceutical Sciences, University of Illinois at Chicago
Location: Chicago, Illinois
Type: Full Time
Required Education: Masters
Academic / Research
College / University
Internal Number: 157639
This position works with the UICentre leadership and project teams to develop, execute and effectively communicate results of molecular, biochemical and cellular assays in support of drug discovery and development. The candidate will support the bioassay and HTS, hit-lead and lead optimization objectives of UICentre using highly specialized knowledge of state-of-the-art equipment and methodologies.
Work within interdisciplinary research teams to design, develop and perform biochemical and cell- based assays in support of hit-to-lead or lead-to-candidate objectives for small molecule drug discovery teams
Design and perform automation protocols to support high and medium throughput screening for small molecule drug discovery efforts
Help manage small molecule libraries to support HTS
Work with cross functional teams to build appropriate strategies for translational science efforts
Effectively communicate bioassay approaches and options for discovery efforts to cross functional teams
Analyze bioassay data and manage transfer and storage of the data in database
Attend UICentre meetings and assist UICentre Director with scientific project management as needed. Contribute to team discussions and decisions regarding new concepts for hit-to-lead optimization, and other
Organize data for presentations and publications, configure slide sets and present research reports to the UICentre members or other research groups
Perform other related duties and participate in special projects as assigned
Interested applicants who meet all of the above criteria should submit a PDF file that includes a cover letter stating career goals, CV, and contact information (including email address and phone number) for three references to : https://jobs.uic.edu/job-board/job-details?jobID=157639 by January 31, 2022.
The University of Illinois at Chicago is an affirmative action, equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, gender identity, sexual orientation, national origin, protected veteran status, or status as an individual with a disability.
Offers of employment by the University of Illinois may be subject to approval by the University’s Board of Trustees and are made contingent upon the candidate’s successful completion of any criminal background checks and other pre-employment assessments that may be required for the position being offered. Additional information regarding such pre-employment checks and assessments may be provided as applicable during the hiring process.
The University of Illinois System requires candidates selected for hire to disclose any documented finding of sexual misconduct or sexual harassment and to authorize inquiries to current and former employers regarding findings of sexual misconduct or sexual harassment. For more information, visit https://www.hr.uillinois.edu/cms/One.aspx?portalId=4292&pageId=1411899
University of Illinois faculty, staff and students are required to be fully vaccinated against COVID-19. An employment offer is contingent on the timely submission of proof of vaccination. If unable to receive the vaccine for medical or religious reasons, an exemption may be sought in accordance with applicable University processes.
Job Knowledge and Skills, Education, Experience
Ph.D. Degree or Masters with 2-4 years’ experience in Biology, Molecular Biology, Biochemistry, Chemistry or related science
Experience with translational science approaches, small molecule drug discovery or high throughput screening
Strong knowledge and hands-on experience with enzyme- and cell-based assays
Experience with common analytical formats for high throughput screening such as FP, TR-FRET, ELISA, reporter assays and AlphaLISA
Knowledge and understanding of statistical validation process for screening assay development
About UICentre-Pharmaceutical Sciences, University of Illinois at Chicago
UICentre is the campus-wide drug discovery initiative at UIC that utilizes existing resources to leverage the expertise of scientist and clinician teams across campus in collaborative engagement in translational research in drug discovery and development.UICentre’s mission is transformative: to use cultural, technical and educational resources at UIC to overcome the obstacles to translational drug discovery.
The expertise of UICentre ranges from target validation and bioassay development to high-throughput screening analysis of novel compound libraries to medicinal chemistry incorporating structure-based, ligand-based and chemo-proteomics assisted drug design, in addition to pre-clinical drug metabolism and pharmacokinetic studies.
Specifically, UICentre seeks to create and support multidisciplinary collaborations that transform basic science projects into team-based drug discovery initiatives at UIC and across the Chicagoland academic community with the long-term objective of improving human health by creating novel drug candidates that can be translated into commercialized therapeutics.