The Indiana University School of Medicine (IUSM) is the largest medical school in the US and is annually ranked among the top medical schools in the US by US News & World Report. Please visit https://medicine.iu.edu for additional information about the Department of Medicine.
We are seeking candidates for a postdoctoral position in the laboratory of Dr. Jaeyeon Kim, an Assistant Professor, in the Department of Biochemistry and Molecular Biology and the Melvin & Bren Simon Comprehensive Cancer Center at Indiana University School of Medicine.
Dr. Kim studies the molecular mechanisms underlying the development and progression of ovarian and breast cancer with genetically engineered mouse models, particularly high-grade serous carcinoma (HGSC) (PLoS Genetics, 2020: 16:e1008808)—the most common, deadliest human ovarian cancer―and triple-negative breast cancer (TNBC). Though originated in disparate tissues, HGSC and TNBC are genomically similar, suggesting a similar mechanism of development. His lab has recently demonstrated that the ovarian hormone progesterone is a crucial endogenous factor inducing metastatic HGSC, and targeting progesterone signaling prevents metastatic HGSC (PNAS, 2020; PMID: 33262282). The genetic similarity between HGSC and TNBC has also led to a study, by creating genetically engineered mouse models of breast cancer, to determine whether progesterone signaling is also critical to TNBC development. Human studies are conceived to test whether targeting progesterone signaling can prevent ovarian and breast cancer in high-risk women, particularly BRCA1-mutation carriers. Moreover, his lab is actively investigating detailed molecular mechanisms underlying progesterone signaling in ovarian cancer development and metastases. Additionally, his lab also focuses on elucidating the role of microRNAs in the development of HGSC using mouse models of Dicer1 or Drosha.
Indianapolis is the 12th largest city in the United States and is growing and thriving economically thanks to a strong corporate base anchored by the life sciences. Indiana is home to one of the largest concentrations of health sciences companies in the nation, which contribute over $44 billion annually to the local economy. The vibrant downtown is a bustling commercial center, entertainment destination and residential neighborhood. The expanding residential base is driven by rich amenities and quality of life – the city is home to a variety of professional sports, arts venues and outdoor recreation areas.
As the nation's largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and well being for all throughout the state of Indiana.
Doctoral or terminal degree required. Research experience with mice or mouse models―accompanied by molecular biology skills, including PCR, QPCR, western blot, cloning, cell culture, and flow cytometry―would be desirable, though not required. Candidates for the postdoctoral position should have, or are expected to receive, a doctoral degree (Ph.D.) in biological or biomedical sciences. Also anticipated are motivation and commitment to research and science with the ability to work independently.
In addition to the research skills and work ethic, what is equally important is community mindedness: that is, willingness to learn and also work collaboratively and harmoniously with other researchers and the principal investigator (PI) in the laboratory. The laboratory will offer a highly interactive, intellectually stimulating yet relaxed research and academic environment. Also, the PI will help promote the career development of researchers in the laboratory. As part of these efforts, besides research training, mentoring and training will also be offered in learning how to write and present their research and science effectively and competitively.
Department Contact for Questions:
Dr. Kim firstname.lastname@example.org or email@example.com
OAA #: IUSM010142016
Internal Number: 10535
About Indiana University Purdue University Indianpolis - IUPUI
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.