The main research focuses of the Nakai lab are: (1) AAV vector biology - capsid assembly, genome packaging, and virus-host interactions; (2) AAV antigen-antibody interactions; (3) developing novel AAV vectors by using cutting-edge technologies; (4) application of data science and machine learning approaches to gene therapy research; and (5) preclinical studies of gene therapy using rodents and non-human primates. The Nakai lab's ongoing projects supported by extramural grants and contracts target the central nervous system, liver, muscle, eye, pancreas and kidney, and the lab is a part of the NIDDK-supported Human Islet Research Network (HIRN). The successful candidate will join a multidisciplinary collaborative team and participate in global collaboration, with an ultimate goal to develop AAV gene therapy for various human diseases. The successful candidate will also contribute to the training of graduate, undergraduate, and high school students, as well as research staff.
The Department of Molecular & Medical Genetics at Oregon Health & Science University (OHSU) in Portland, Oregon, is seeking a highly motivated and enthusiastic post-doctoral fellow to study adeno-associated virus (AAV) and its application for human gene therapy in the lab led by Professor Hiroyuki Nakai, M.D., Ph.D. Specifically, the lab is looking for a post-doctoral researcher who can lead productively projects that aimed at developing novel AAV capsids using TRADE (TRanscirption-dependent Directed Evolution), a novel non-coding mRNA-based AAV capsid engineering method established in the Nakai lab, and studying their applications using various animal models. In addition, the successful candidate will participate in studies that intensively investigate the biology of AAV to understand the fundamental principles behind the virus-host interactions relevant to the development of novel molecular therapies for various diseases. There are various opportunities for post-doctoral fellows to lead currently ongoing projects and new projects.
Salary for this position aligns with the NIH Scale .
PhD
Substantial knowledge and skills in molecular biology
Ability to perform multiple tasks at one time
Ability to organize and handle a large quantity of samples and data
PhD in a relevant field, MD, DVM or MD/PhD
Strong enthusiasm and dedication for AAV and gene therapy research
Willingness to work on non-human primate studies
Apply here online. Please be sure to upload a cover letter and Resume or CV.
Oregon Health & Science University values a diverse and culturally competent workforce. We are proud of our commitment to being an equal opportunity, affirmative action organization that does not discriminate against applicants on the basis of any protected class status, including disability status and protected veteran status. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. To request reasonable accommodation contact the Affirmative Action and Equal Opportunity Department at 503-494-5148 or aaeo@ohsu.edu.
As the state's only health and research university, OHSU brings together patient care, research, education of the next generation of health care providers and scientists and community service to improve the health and well-being of all Oregonians.The university is a conduit for learning for more than 2,800 students, providing training to interns, residents and fellows in postgraduate medical and research. It is the only place in Oregon that grants doctoral degrees in medicine, dentistry and nursing. OHSU cares for more than 251,000 patients each year from around the region and takes a leadership role in contributing to solutions involving the health of the state and the nation, such as health care access and transparency, ethics and workforce shortage. Beyond providing critical health care services, quality education and cutting-edge research, OHSU also is a key economic and social force in the Northwest. With an annual operating budget of $2.06 billion and more than 14,000 employees, OHSU is Portland?s largest employer. Its size contributes to its ability to provide... many services and community support activities not found anywhere else in Oregon. For more information visit http://www.ohsu.edu/xd/about/index.cfm
