A postdoctoral position is available in the laboratory of Dr. Jessica MacDonald in the Department of Biology at Syracuse University. The broad goal of the research in our lab is to understand genetic and epigenetic mechanisms that regulate development and function of the neocortex, and how life-long environmental exposures (such as nutritional factors) intersect with fixed genetic susceptibilities to alter neuronal development and cognitive function. We are particularly interested in disruptions in these mechanisms that lead to neurodevelopmental disorders, and one current focus of the lab is the severe neurological disorder Rett syndrome, caused by mutations in the epigenetic regulator MeCP2. We are identifying molecular and cellular pathways that are disrupted in this disorder, and investigating potential therapeutic avenues that target these disrupted pathways to ameliorate Rett syndrome phenotypes.
Internal Number: 85580
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