The Walensky laboratory focuses on the chemical biology of deregulated protein interactions in cancer, metabolism, and infectious diseases. Our goal is to develop and deploy an arsenal of new compounds to dissect and target pathologic protein interactions using multidisciplinary approaches that include (1) chemical and stapled peptide design, (2) rigorous biochemical, proteomic, and structural characterizations, (3) mechanistic validation in cells and mouse models, and ultimately (4) clinical translation. We emphasize mechanistic biology, including (1) canonical and non-canonical roles of BCL-2 family apoptotic proteins, (2) the p53 and RAS pathways, (3) high priority metabolic, bacterial and viral targets, and (4) novel helix-in-groove interactions relevant to protein structure, function, and drug development
See the Walensky groupâ€™s most recent publications for a sampling of the labâ€™s research projects and their multidisciplinary approach to scientific investigation.
We are currently seeking highly accomplished PhD candidates/graduates applying for postdoctoral fellowship training in chemical, cellular, or translational biology in the areas of cancer, metabolism and infectious diseases. We are particularly interested in candidates with expertise in structural biology, biochemistry, proteomics, molecular and cellular biology, and/or mouse modeling. Interested applicants should send a CV, including a list of three references through the provided link.
Internal Number: 2021-21304
About Dana-Farber Cancer Institute
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to under-served members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.