The Department of Pharmacology at the University of Washington School of Medicine invites applications for a Research Assistant Professor focusing on voltage-gated sodium channels in structural biology. Voltage-gated sodium channels initiate action potentials in nerve and muscle. We aim to use structural biology methods to understand the mechanism of voltage-dependent activation and inactivation of sodium channels at the atomic level and learn how these mechanisms are altered by mutations that cause periodic paralysis, chronic pain, epilepsy, and autism. This position will lead a research program on the structure, function, and molecular pharmacology of voltage-gated sodium channels. Research objectives will be to determine the structure of sodium channels in multiple functional states, determine the structures of complexes of sodium channels with toxins and drugs bound to them, and analyze the functional significance of these drug and toxin interactions. The work will use a combination of biochemical, structural, and pharmacological methods. The position will jointly guide the research of graduate students and postdoctoral fellows with Dr. William Catterall. They will develop grant funding for research projects and will serve as Principal Investigator on those research grants. Consistent with Research Assistant Professor appointments, the successful candidate will have teaching roles in two Pharmacology courses. This position will use molecular biology, protein expression and purification, and structure determination by x-ray crystallography and cryogenic electron microscopy.
This is a non-tenured, full-time position anticipated for a minimum three-year appointment. This is a twelve-month appointment with salary paid over twelve months for eleven months of service with an estimated start date of February 1, 2021
The successful candidate is expected to establish independent research funding. University of Washington Faculty members engage in teaching, research, and service, with a majority of effort in research for appointment as Research Assistant Professor.
Additional information about the Department and its current research interests may be obtained at https://pharmacology.uw.edu/team-member/william-catterall/.
A Ph.D. degree (or foreign equivalent) in Biochemistry, Structural Biology, or a related field. Eight years of experience and published peer-reviewed scientific papers in structural studies of sodium channels and other membrane proteins are required. An in-depth understanding of the integration of structural and functional studies of sodium channels is essential.
For full consideration, please submit a curriculum vitae and statement of research interests, and arrange for five letters of recommendations through Interfolio. CVs without accompanying letters of recommendation do not qualify as a full application and will not be considered.
University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, creed, religion, national origin, sex, sexual orientation, marital status, pregnancy, genetic information, gender identity or expression, age, disability, or protected veteran status.
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