The Project Scientist in the role will focus on studying the role of microglia in Alzheimer's Disease pathogenesis and evaluating molecules that can augment microglial function and neurotoxic Amyloid-beta (A b ) processing and homeostasis in the brain. You must hold a doctoral degree (preferably with expertise in microglia biology and Alzheimer's disease, but at a minimum with neuroscience, neurobiology, molecular biology or a closely related field). The successful candidate should have a minimum of 3 years of experience as a scientifically productive post-doctoral fellow and must have experience with translational research using animal models to study mechanisms of gene function and disease pathogenesis. Experience in molecular biology, cell culture, immunocytochemistry, Western blotting, PCR, quantitative real-time PCR and histology/imaging techniques including quantitative bright-field and fluorescence microscopy and confocal microscopy is required. Experience with proteomics analysis of isolated protein complexes will be beneficial for some of the planned protein-protein interaction experiments. Will be expected to independently design and conduct experiments, collect and analyze data, troubleshoot experimental protocols, consolidate data for publication and grant applications, present research at national and international meetings, and prepare manuscripts for publication. Teaching and supervising other research staff, students, and residents may be required.

You will work independently and in cooperation with the Principal Investigator to make significant and creative contributions to the assigned research project. The research projects assigned are developed under the direction and in collaboration with the Principal Investigator, Warren Tourtellotte, MD, PhD, Professor and Vice-Chair of Pathology and Laboratory Medicine and Professor of Neurology, Neurosurgery and Biomedical Sciences. You will be expected to have substantial scientific independence, organization, creativity and motivation. A significant track-record of scholarly productivity and strong evidence of successful independent experimental design and execution is expected and essential.