The Project Scientist in the role will focus on studying the role of microglia in Alzheimer's Disease pathogenesis and evaluating molecules that can augment microglial function and neurotoxic Amyloid-beta (A b ) processing and homeostasis in the brain. You must hold a doctoral degree (preferably with expertise in microglia biology and Alzheimer's disease, but at a minimum with neuroscience, neurobiology, molecular biology or a closely related field). The successful candidate should have a minimum of 3 years of experience as a scientifically productive post-doctoral fellow and must have experience with translational research using animal models to study mechanisms of gene function and disease pathogenesis. Experience in molecular biology, cell culture, immunocytochemistry, Western blotting, PCR, quantitative real-time PCR and histology/imaging techniques including quantitative bright-field and fluorescence microscopy and confocal microscopy is required. Experience with proteomics analysis of isolated protein complexes will be beneficial for some of the planned protein-protein interaction experiments. Will be expected to independently design and conduct experiments, collect and analyze data, troubleshoot experimental protocols, consolidate data for publication and grant applications, present research at national and international meetings, and prepare manuscripts for publication. Teaching and supervising other research staff, students, and residents may be required.
You will work independently and in cooperation with the Principal Investigator to make significant and creative contributions to the assigned research project. The research projects assigned are developed under the direction and in collaboration with the Principal Investigator, Warren Tourtellotte, MD, PhD, Professor and Vice-Chair of Pathology and Laboratory Medicine and Professor of Neurology, Neurosurgery and Biomedical Sciences. You will be expected to have substantial scientific independence, organization, creativity and motivation. A significant track-record of scholarly productivity and strong evidence of successful independent experimental design and execution is expected and essential.
Summary of Essential Job Duties:
Will publ ish research as author or co-author, and present progress reports at meetings and seminars.
Analyzes, interprets, summarizes and compiles data for publication.
May develop, adapt and implement new research techniques and protocols .
May assist in preparation of grant proposals, submissions, publications and presentations, but is not responsible for generating grant funds.
May serve as PI for certain grants as approved by Principal Investigator.
May lead or train Staff Research Associates and Research Fellows.
Will assist in day-to-day laboratory activities.
Appointees on an academic trajectory will be expected to commit a portion of their time to developing an independent range of research.
PhD or highest degree in their field is required
Demonstrated significant, original, and creative contributions to a research or creative program or project c ompletion of postdoctoral appointment in area of specialization, as applicable.
Completion of postdoctoral appointment in area of specialization, as applicable. Knowledge of PI's area of research specialization.
Demonstrated technical competency in a variety of research techniques and protocols.
Working Title: Project Scientist (Alzheimer's Disease) - Pathology Group Operations - Tourtellotte Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.