Post-doctoral position available immediately at Northwestern University in the Feinberg School of Medicine in the Department of Urology. We have received substantial recent funding to identify mechanisms associated with cancer progression in bladder cancer. We are seeking enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. Applicants must have a strong track record and research background in molecular and cell biology with an interest in translational research. Experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: epigenetics, immunology, functional genomics or other high-throughput screening methods, in vivo tumor models, advanced microscopy methods, and biochemistry.
What We Offer:
Our international team offers an open, supportive, dynamic and motivating academic environment with excellent training opportunities with the possibility to work on cutting edge and novel translational research projects. We use a wide spectrum of methods: biochemistry, cloning, cell culture, qRT-PCR, FACS, ELISA, cell-based assays (proliferation, apoptosis, migration, 3D invasion, organoid culture, shRNA and CRISPR screens, proteomics, transactivation assays, virally-based gene delivery, RNAi and CRISPR silencing, immunohistochemistry, in situ hybridization, light, epifluorescence and confocal microscopy, image analysis, next generation sequencing, chromatin immunoprecipitation, single-cell RNA-seq, bioinformatic analysis, animal models and in vivo tumor models as well as tumor biopsies.
We have won a number of external research grants and are involved in several national and international collaborative projects. Significant time is spent developing critical research skills and scientific writing and editing. Potential for training grant and independent funding depending on qualifications.
The selected candidate will work on the genetic, epigenetic, and immune mechanisms of cancer biology and epigenetic-based therapies in bladder cancer. This fellowship will use bladder cancer as a model system for solid-tumor biology to better investigate tumor development, epigenetic modifications and immune response to cancer. No prior experience with bladder cancer is required, but candidates should have an interest in molecular biology, solid tumor cancer and epigenetics.
The main focus of the lab is related to: 1) how does histone modification affect tumor aggressiveness and can this be used as a therapy? 2) How do epigenetics affect immune response? Our overall goal is to improve outcomes for patients with urologic cancers by focusing on the development and translational application of novel therapeutics.
Research projects associated with this fellowship may include:
What the mutations and expression changes that drive bladder cancer development?
What are the spatial and immune regulatory changes that occur in bladder cancer?
How do carcinogens result in the development of bladder cancer?
Does bladder cancer develop differently in males and females?
PhD or MD/PhD
Desire for independent research
Experience in bioinformatics (R, Python) and animal models
Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
Internal Number: 39795
About Northwestern University
Northwestern University is a major private research university with 12 academic divisions located on three campuses in Evanston, Chicago, and Education City in Doha, Qatar. We have approximately 2,500 full-time faculty members, 17,000 graduate and undergraduate students, and over 5,700 full and part-time staff. Northwestern University combines innovative teaching and pioneering research in a highly collaborative environment. It provides students and faculty exceptional opportunities for intellectual, personal and professional growth.