Position Summary: A position for a Postdoctoral Research Associate in Electrophysiology and Neuroscience is available in the laboratory of Dr. Peng Jiang in the Department of Cell Biology and Neuroscience, Rutgers University New Brunswick. The research theme of the laboratory is on investigating cellular and molecular basis of human neural development and pathogenesis of neurological disease utilizing human induced pluripotent stem cells (hiPSCs). We focus on (i) Establishing patient-derived and disease-specific hiPSCs; (ii) Modeling neurodevelopmental and neurodegenerative disorders (e.g. Down's syndrome and Alzheimer's disease) and finding new therapeutics using hiPSC-based in vitro brain organoid and in vivo human-mouse chimeric brain models; and (iii) Differentiating hiPSCs towards neural lineages for regenerative medicine and developing hiPSC-based cell therapies utilizing animal models of human CNS injuries (e.g. brain hypoxic-ischemic injury). We have been using a combination of multidisciplinary techniques in our research, including stem cell reprogramming, electrophysiology/patch-clamp recording, imaging techniques, molecular/cell biology (including CRISPR/Cas9), biochemistry, pharmacology, bulk and single cell RNA-sequencing techniques, transgenic and surgically induced animal models, and animal behavioral testing. For more information about our research, please see our recent representative publications: A full list of our publications can be found here: https://www.sas.rutgers.edu/cms/cbn/peng-jiang-lab/353-publications) We are looking for individuals who are interested in working on differentiation of human pluripotent stem cells to neural cells or tissues, and application of these stem cell technologies to the development of in vitro and in vivo models for better understanding human brain development and disease and for drug screening/discovery. Minimum Education and Experience: Candidates should have a good publication record and a Ph.D. in neuroscience, stem cell biology or related fields. Candidates must have extensively experience with both in vitro and in brain slice electrophysiology and performing patch-clamp recordings for pre- and post-synaptic transmission and long-term potentiation. Experiences with stem cell culture and differentiation, molecular and biochemical assays, and animal work are desired. Posting Number: 19FA2443 Location: Busch (RU-New Brunswick)
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