The Theodorescu Lab at Cedars-Sinai in Los Angeles, along with collaborators, has made significant contributions in the area of cancer biology and therapeutics. These contributions include discovery and development a "first in class" RalGTPase inhibitor as a new therapeutic in several human cancer types (Nature. 2014 20;515(7527):443-7). Using functional genomics screens (including CRISPR, shRNA and cDNA library use) and transcriptomics on human cell lines and tumor tissues we have identified several candidate genes that confer resistance to commonly used chemotherapeutics and immunotherapy (i.e. checkpoint inhibitors) in bladder cancer and other tumors. We are seeking a highly motivated research scientist / postdoctoral fellow / postdoc, to further develop this work by defining the mechanism of action of how these genes alter resistance to chemotherapeutics, targeted small molecules and biological agents (antibodies, peptides etc...) directed at either the cancer cell or the tumor microenvironment (e.g. immunotherapy, checkpoint inhibitors). The laboratory has ongoing discovery projects directed at key molecules driving cancer growth, metastasis and tumor microenvironment (TME, stroma/fibroblast) which are being evaluated as candidates for therapeutic targeting and clinical translation to trials in patients.
This individual would join our exciting cancer research group. The successful candidate will be a driven, creative, team-oriented individual with a passion for helping to discover and move fundamental cancer biologic findings towards a clinical setting. The candidate will have a PhD or MD/PhD degree and background in functional genomics (including CRISPR, shRNA and cDNA library use) and next generation sequencing. A broad-based knowledge of cancer biology, immunology and signal transduction is an important characteristic of the successful applicant. We welcome applications who are completing their PhD as well as individuals seeking additional postdoctoral training. Strong preference will be given to individuals with an outstanding publication record from their prior graduate and/or postgraduate training and/or existing external funding.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.