The Gene Editing Institute is the only research institute of its kind in the nation based within a community health care system. Led by gene editing pioneer, Eric Kmiec, Ph.D., and based in ChristianaCare's Helen F. Graham Cancer Center & Research Institute, the Gene Editing Institute is a worldwide leader in gene editing biomedical research in cancer and other inherited diseases, and the only one working in the same space with oncologists, genetic counselors and patients, bringing translational research from basic science to patient treatment to an entirely new level.
Christiana Care is currently seeking a Research Scientist II - CRISPR Gene Therapy to work in the Gene Editing Instituteat our Helen F. Graham Cancer Center. The Research Scientist II will participate in all aspects of preclinical development work in new, targeted delivery system utilizing CRISPR gene therapy to treat NSCLC. The successful candidate will work on the design and optimization of CRISPR vectors in experimental lung cancer models. The candidate is also expected to develop proof-of-concept and preclinical studies for other solid cancers. The ideal candidate will have advanced expertise in CRISPR gene therapy and also in oncology, cell biology, molecular biology or biochemistry.
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide and in the United States. There is a high unmet need for new treatment options to treat NSCLC due to the high rate of chemoresistance in NSCLC. Gene Editing Institute at Christiana Care Health System has identified a specific target to reduce the chemoresistance and is currently developing CRISPR gene therapy strategy to treat NSCLC. This platform protocol is also applicable to other cancers.
Other responsibilities to include:
Be involved in the planning and execution of all aspects of preclinical development work for CRISPR gene therapy programs
Lead laboratory research related to in silico, in vitro, and in vivo off-target analysis and characterizations for gene therapy products in preclinical research
Perform CRISPR gRNA design, knockout / knock-in experimentation, and characterizations in in vitro and in vivo cell models
Develop and implement proof-of-concept and preclinical research in solid tumor gene therapy
PhD in cancer biology, molecular biology, cell biology, biochemistry, or a closely related field.
Minimum of 3 - 7 years of industry experience.
Candidates should also have authored at least two first author publication (either published or in the process of submission) in reputable journals; cancer research experience preferred.
Must be proficient in CRISPR off-target analysis tools, CRISPR technology and its clinical application, cell-based models and in utilization of murine models, and performing cell biology, biochemistry, and molecular biology techniques.
Internal Number: JR53995
About Christiana Care Health System
Christiana Care Health System is headquartered in Wilmington, Delaware and is one of the country's largest health care providers, ranking 21st in the nation for hospital admissions. Christiana Care is proudly a Nurse Magnet recognized institution. Christiana Care Health System is also one of the largest health care providers in the mid-Atlantic region, serving all of Delaware and portions of seven counties bordering the state in Pennsylvania, Maryland and New Jersey. A not-for-profit, non-sectarian health system, Christiana Care includes two hospitals with more than 1,100 patient beds, and is a major teaching hospital with two campuses. Christiana Care is continually recognized for excellence on a regional and national level. Our role in the community is expressed in the Christiana Care Way: "We serve our neighbors as respectful, expert, caring partners in their health. We do this by creating innovative, effective, affordable systems of care that our neighbors value."Christiana Care is a great place to work because we value diversity and recognize it to be a core part of our success. Because of the diversity of our employees, affiliated health professionals and volunteers, we are... positioned to meet the unique needs of our patients and community. We acknowledge and celebrate the uniqueness and talent of each employee. Because of our talented workforce we are able to provide a quality healthcare experience to our patients and community. We strive to create an inclusive environment in which individual diversity can be leveraged and thrive. Christiana Care Health System is an equal opportunity employer, firmly committed to prohibiting discrimination, whose staff is reflective of its community and considers qualified applicants for open positions without regard to race, color, sex, religion, national origin, sexual orientation, genetic information, gender identity or expression, age, veteran status, disability, pregnancy, citizenship status, or any other characteristic protected under applicable federal, state, or local law.