The Nieuwkoop lab seeks a post-doctoral researcher to help start a project on the structural biology of the PTEN protein. Specifically, we seek to understand the functional role of PIP binding by the C2 domain of PTEN. The PTEN C2 domain will be expressed with isotopic labeling to for backbone and side-chain NMR assignments as nanocrystals and bound to its PIP ligand in liposomes. This project will depend on novel ssNMR experiments, optimized sample preparation, and specialized NMR equipment to assess structural and dynamical changes in the bound and unbound protein.
Minimum Education and Experience:
Applicants should have or be about to receive a Ph. D. in Chemistry, Chemical Biology or a related field.
Required Knowledge, Skills, and Abilities:
Applicant should be knowledgeable in recombinant protein expression and purification. Experience in the use of NMR to characterize proteins will be an evaluation criteria and experience with solid-state NMR an major plus.
Physical Demands and Work Environment:
No substantial physical demands. Work will be carried out in a brand-new laboratory in the recently opened Chemistry and Chemical Biology building. All equipment was purchased new within the last 2 years.
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