Department: COP Drug Discovery and Biomedical Sciences
Advertised Job Summary:
The Zhu lab in the Department of Drug Discovery and Biomedical Sciences at the College of Pharmacy, University of South Carolina is seeking an accomplished and motivated Postdoctoral Fellow to work on ongoing R01 project funded by the National Institute of Drug Abuse. The R01 project is to develop small molecule allosteric inhibitors of the dopamine transporter (DAT) that can block or diminish HIV-1 regulatory protein, transactivator of transcription (Tat) protein-induced inhibition of the reuptake of dopamine through DAT, which has potential therapeutic approaches for the treatment of HIV-1 infection associated neurocognitive disorders. The ideal candidate will be required to characterize the in vitro pharmacological profile of the compounds to identify optimized probe molecules using cell based expressing human DAT. The ideal candidate will be required to determine the therapeutic role of novel allosteric modulators in alleviation of Tat-mediated cognitive deficits and rewarding effects of cocaine in inducible Tat transgenic mice. This multidisciplinary approach include studies using cell culture (cells expressing human dopamine transporter, and its mutants), radioligand uptake/binding, Co-IP and GST pull-down assays, cell surface biotinylation, transporter-mediated uptake and release, transgenic HIV-1 Tat transgenic mouse model, single residue on dopamine transporter knock in mouse model and behavioral testing.
Additional information about Zhu's laboratory is available at: http://www.sc.edu/study/colleges_schools/pharmacy/faculty-staff/zhu_jun.php
Advertised Minimum Qualifications :
Successful candidates should have a Ph.D. in Neuroscience, neuropharmacology, behavior pharmacology or related discipline. Candidates with training or experience in regulation of membrane transporter function and expression are encouraged to apply.
Full/Part Time: Full Time
Internal Number: 86428
About The University of South Carolina
The University of South Carolina System is comprised of the state’s flagship university in Columbia (founded in 1801 and currently one of the top 50 “Best Colleges” according to U.S. News and World Report), three regional comprehensive universities (USC Aiken, USC Beaufort and USC Upstate), and Palmetto College consisting of four two-year campuses (USC Lancaster, USC Salkehatchie, USC Sumter, USC Union and Fort Jackson/Extended University). Together, the USC System institutions offer more than 450 degree programs on campus and online and are uniquely positioned to meet the state’s educational, cultural, health and research needs. The System employs nearly 14,000 people who work daily to improve the lives of students, fellow South Carolinians and the world. Our diverse engaged faculty and staff enjoy a dynamic and intellectually stimulating work environment.