As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem solving skills and dedication to build stronger minds and a healthier world.
UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits and natural beauty. All of which has allowed the UW to be nationally recognized as a “Great College to Work For” for six consecutive years.
The University of Washington (UW) School of Medicine (SOM) Departments of Laboratory Medicine and Pathology become a single Department of Laboratory Medicine and Pathology (DLMP) on July 1, 2020. The DLMP employs ~ 130 faculty, 800 staff, 60 residents and fellows, and 50 post docs and graduate students, with an annual budget of over $200 million: ~ $141 million in the SOM and ~$65 million in UW Medicine. A regional resource for clinical laboratory services required for cutting edge patient care, research and educational programs, we combine the sophisticated testing and informatics capabilities of fully accredited laboratories with the resources of an academic institution in its delivery of clinical and anatomical pathology services. Recognized for excellence in clinical training, world-class research initiatives, and a commitment to community service, we serve the five state WWAMI region: WA, WY, AK, MT, and ID.
We offer over 30 graduate medical education programs, including 18 subspecialty clinical fellowships (ACGME & Non-ACGME), a residency program in clinical and anatomical pathology, a clinical research fellowship, a post sophomore fellowship, and 13 medical student clerkships. Our graduate programs provide innovative educational opportunities to developing medical practitioners and bio clinical researchers. The Molecular Medicine and Mechanisms of Disease (M3D) PhD Program trains students to use advances in basic sciences to solve problems relevant to human disease; and, to use insights from human disease processes to solve fundamental biological problems. The UW Medical Scientist Training Program (MSTP) is a dual degree MD/PhD program between the SOM and UW Research. The program trains scientists to develop a broad knowledge in medicine and the ability to productively investigate detailed mechanisms associated with human diseases.
Our operations are based at the University of Washington School of Medicine, University of Washington Medical Center, Harborview Medical Center, and the Seattle Cancer Care Alliance. Faculty members also serve at Seattle Children's Hospital, the Veteran’s Administration Puget Sound Healthcare System, and the Fred Hutchinson Cancer Research Center. Our collaborative efforts have generated innovative, translational studies in the basic mechanisms of disease as they apply to diagnostic clinical and anatomical pathology. The UW is proud to be one of the nation’s premier educational and research institutions. Our people are the most important asset in our pursuit of achieving excellence in education, research, and community service.
The Crispe Laboratory is seeking a full-time grant-funded Research Scientist/Engineer 2.
Research Support (80%):
• Performing experiments to test hypotheses concerning T cell immune tolerance in the mouse liver, using an experimental model based on Adeno-Associated Virus gene therapy vectors. •Maintain, breed and type multiple lines of gene-targeted mice. •Generate and test Adeno-Associated Virus vectors, titer them, and use them to deliver genes of interest in vivo. •Isolate T cells and other cell populations from normal and gene-targeted mice. •Deliver T cells by adoptive transfer. •Measure liver injury using histopathology, gene expression markers and serum markers •Isolate cells from the mouse liver and analyze their surface markers by FACS and the gene expression by qRT-PCR.
Laboratory Operations (10%):
• Being organized, focused and attentive to assigned tasks. • Attending in weekly lab meetings and presenting reports. • Assisting with stocking and ordering of lab supplies, receiving deliveries.
• Maintaining accurate and logical records of scientific data, including a well-organized lab notebook as well as computer records. • Assisting in preparation of laboratory reports, data analyses, manuscripts, and poster presentations using Excel, PowerPoint and Prism.
•Bachelor's Degree in Chemistry, Biology or other Biological Sciences with a minimum of two years of hands-on experimental work using small animal models. •Basic understanding of immunology, specifically in relation to T cells, antigen-presenting cells and immune tolerance. •Experience working with mice. •Experience with flow cytometry. •Ability to work and collaborate with other lab members •Ability to work flexible hours based on experiment needs •Willingness to learn and assist in secondary tasks.
Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration.
•Five years of hands-on experimental work using small animal models or a Master’s Degree with two years of relevant experiences •Experience working with virus-based vectors. •Experience with data analysis using Prism.
As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here.
The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.