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Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Cardiology. This position is for the Medical School Campus.
A postdoctoral research associate position is available in the laboratory of Dr. Stacey Rentschler at Washington University School of Medicine. Our lab investigates the transcriptional and epigenetic mechanisms regulating programming of electrophysiological phenotypes. Our group demonstrated that reactivation of developmental signaling pathways including Notch and Wnt can electrically remodel cardiomyocytes, or “reprogram” them, to adopt a new electrical phenotype in animal models (Rentschler et al, Journal of Clinical Investigation, 2011; Rentschler et al, Circulation, 2012; Gillers et al, Circulation Research 2015). In heart failure, reactivation of the Notch signaling pathway may contribute to transcriptional changes influencing ion channel gene expression that may predispose to the development of lethal arrhythmias (Khandekar et al, Circulation Research 2016). In contrast, reactivation of distinct signaling networks within adult myocardium may provide new avenues for regenerative medicine approaches for the treatment of arrhythmias, such as in the development of a biological pacemaker (Meyers et al, Trends in Cardiovascular Medicine, 2015).
We have developed methodology for culturing organotypic cardiac slices. Functional readouts include optical mapping with voltage-sensitive dyes to visualize and quantify electrophysiological properties, as well as microelectrode recordings to assess changes in cellular physiology. In addition, we are performing genome-wide gene expression and epigenetic studies on mouse and human cardiac tissue to decipher the complex regulatory mechanisms that govern expression of important regulators of electrophysiology within regions of the heart in both health and disease states. This methodology will allow us to test the response of human cardiac tissue to selected therapeutics, with the goal of expediting the prolonged process involved in getting new therapeutics validated for use in humans.
The successful applicant will be responsible for executing experiments involving handling of tissue, as well as working with mouse models.
Ph.D., M.D. or an equivalent terminal or doctoral degree.
Will graduate soon, or have recently completed their doctoral degree.
Highly motivated with a track record of productivity.
Works well independently, as well as enjoys working together on a team.
Extensive background in gene expression and/or epigenetics.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Interested candidates should email a single PDF file that includes a cover letter and CV together with the names of two referees with contact information to Stacey Rentschler, M.D., Ph.D. at Stacey.firstname.lastname@example.org.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
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