Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute (the Zuckerman Institute) brings together researchers to explore aspects of mind and brain, through the exchange of ideas and active collaboration. The Zuckerman Institute’s home will be the Jerome L. Greene Science Center on Columbia’s new Manhattanville campus. Situated in the heart of Manhattan, at full capacity the Zuckerman Institute will house approximately 47 laboratories employing a broad range of interdisciplinary approaches to transform our understanding of the mind and brain. In this highly collaborative environment, labs work together to gain critical insights into human health by exploring how the brain develops, performs, endures and recovers from trauma or disease.
A lab within the Zuckerman Institute seeks an Associate Research Scientist (ARS) to facilitate research in the representation of the molecular building blocks of Alzheimer's disease, Parkinson's and other devastating neurodegenerative diseases. The Fitzpatrick lab leverages the latest developments and technology including cryo-electron microscopy with complementary biophysical techniques (proteomics, light-microscopy, microfuids) to explore the molecular and structural basis of neurodegeneration. Techniques are used to determine the structure and behavior of amyloid fibrils, purified directly from postmortem brain tissue as well as understanding the role of protein aggregation in vivo by visualizing the cellular changes that occur in response to the formation, clearance and spread of fibrillary inclusions using light-microscopy and cryo-electron tomography. The Associate Research Scientist will utilize molecular and biochemical expertise to synthesize proteins and process brain tissue samples for analysis by cryo-EM imaging. They will maintain laboratory operations and databases, monitor stocks and process imaging data and prepare results for publication. The ideal candidate will have expertise in visually guided behavior and strong computational skills, as well as superior motivation, drive and demonstrated aptitude for research.
Internal Number: 6027
About Columbia University
Columbia University is one of the world's most important centers of research and at the same time a distinctive and distinguished learning environment for undergraduates and graduate students in many scholarly and professional fields. The University recognizes the importance of its location in New York City and seeks to link its research and teaching to the vast resources of a great metropolis. It seeks to attract a diverse and international faculty and student body, to support research and teaching on global issues, and to create academic relationships with many countries and regions. It expects all areas of the university to advance knowledge and learning at the highest level and to convey the products of its efforts to the world.