Summary Description: Columbia University’s Mortimer B. Zuckerman Mind Brain Behavior Institute (the Zuckerman Institute) brings together researchers to explore aspects of mind and brain, through the exchange of ideas and active collaboration. The Zuckerman Institute’s home will be the Jerome L. Greene Science Center on Columbia’s new Manhattanville campus. Situated in the heart of Manhattan, at full capacity the Zuckerman Institute will house approximately 47 laboratories employing a broad range of interdisciplinary approaches to transform our understanding of the mind and brain. In this highly collaborative environment, labs work together to gain critical insights into human health by exploring how the brain develops, performs, endures and recovers from trauma or disease. A lab within the Zuckerman Institute seeks an Associate Research Scientist (ARS) to facilitate research in the representation of the molecular building blocks of Alzheimer's disease, Parkinson's and other devastating neurodegenerative diseases. The Fitzpatrick lab leverages the latest developments and technology including cryo-electron microscopy with complementary biophysical techniques (proteomics, light-microscopy, microfuids) to explore the molecular and structural basis of neurodegeneration. Techniques are used to determine the structure and behavior of amyloid fibrils, purified directly from postmortem brain tissue as well as understanding the role of protein aggregation in vivo by visualizing the cellular changes that occur in response to the formation, clearance and spread of fibrillary inclusions using light-microscopy and cryo-electron tomography. The Associate Research Scientist will utilize molecular and biochemical expertise to synthesize proteins and process brain tissue samples for analysis by cryo-EM imaging. They will maintain laboratory operations and databases, monitor stocks and process imaging data and prepare results for publication.
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