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RESEARCH TECHNICIAN , Biology , to join a research team studying the post-transcriptional regulation of gene expression in mammalian systems. The work will involve cloning, protein expression and purification, in vitro RNA synthesis, protein-RNA interaction assays, and various aspects of next-generation sequencing technology including preparation of libraries for sequencing and analysis of RNA sequencing data. Previous work from the lab has shown that most alternative splicing events in humans are regulated in a tissue-specific manner (Nature 456, 470-476, 2008). RNA binding proteins (RBPs) guide this extensive post-transcriptional regulation. As a part of a multi-lab collaboration to globally map in vivo binding sites of RBPs and to define/predict post-transcriptional roles of mammalian RBPs ( https://www.biorxiv.org/content/early/2018/10/05/179648 ), biochemistry and molecular biology tools (similar to those in Mol Cell 54, 887-900, 2014, Methods in Enzymology 558, 465-493, 2015, Mol Cell 64, 294-3-6, 2016, and Mol Cell 70, 854-867.e9, 2018) will be used to characterize RNA sequence and structural binding preferences of several dozen RBPs.
Job Requirements REQUIRED : biochemistry or molecular biology lab experience, familiarity with molecular biology techniques, self-motivation, strong organizational skills, and a high school diploma. PREFERRED : experience with protein purification and/or bioinformatics and a bachelor's degree in biochemistry, genetics, or biological sciences. Job #18838-4
Occasional night and weekend work might be required.
This is a temporary position for the term of one year with the possibility of extension based on funding and performance.
Internal Number: 18838
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