Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Nephrology Division. This position is for the Medical School Campus.
An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Division of Nephrology. Endoplasmic reticulum (ER) dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD), acute ischemic kidney injury, and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. The posted position will focus on mechanism investigation, novel signaling pathway identification and therapeutic intervention in the area of podocyte ER stress and ER calcium dyshomeostasis (Proc Natl Acad Sci 116: 14154-14163, 2019; JCI Insight 2(23): e92896 2017; J Am Soc Nephrol 27: 2974-2982 2016; J Am Soc Nephrol 24: 1223-1233 2013; one issued patent related to the discovery of two ER stress biomarkers). We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and CRISPR generated knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro & in vivo imaging techniques. We also have access to multiple kidney disease consortiums to acquire their genomic data, gene expression, histology from kidney biopsies, and urine samples. The PI’s research has been funded by multiple grants from NIH, Department of Defense etc. and industry. The lab environment is highly supportive.
A PhD or MD/PhD degree in biochemistry, molecular biology, molecular genetics or other related fields.
A strong background in molecular biology or biochemistry.
Experience with ER or podocyte biology, mouse genetic models, or kidney-related research is highly desired.
The Washington University Division of Nephrology (https://renal.wustl.edu) is a top research-focused academic division. The research environment is outstanding.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Applicant Special Instructions:
Interested candidates should email a CV, cover letter and the names of three references to:
Y. Maggie Chen, MD, PhD
Associate Professor of Medicine
Director, Nephrotic Syndrome Clinic Division of Nephrology Washington University School of Medicine Box 8126 660 S. Euclid Avenue St. Louis, MO 63110
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.