A position for a post-doc will be available in the laboratory of Dr. Jlenia Guarnerio at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center. The appointments will be for 1-3 years with the possibility for extension based on productivity and research.
Cedars-Sinai Medical Center ranks among the nation's top ten non-university hospitals receiving federal funding for research and currently has more than 1,500 active research projects. Cedars-Sinai Cancer Center supports basic and clinical research in many cancer-related areas and researchers are seeking more effective ways to diagnose, treat and prevent many forms of cancer.
Cedars-Sinai is situated in the heart of Los Angeles at the border with Beverly Hills, in a very dynamic area of the city, and in the proximity of the University of California Los Angeles (UCLA). Ongoing education and training are offered throughout the institute, with the possibility to promotions to positions of instructor. Competitive salary and excellent benefits are also provided.
Guarnerio Lab : Cedars-Sinai Cancer
Our lab's goal is to understand the interactions between highly aggressive cancers and the non-malignant cells of the microenvironment in order to identify molecular vulnerabilities and develop novel therapies, especially in sarcoma and leukemia. We work in a highly collaborative environment incorporating functional genomics, proteomics and biochemistry approaches that include single-cell and spatial single-cell transcriptomics, mass-cytometry, Hyperion imaging, and state of art mass spectrometry technologies.
We are seeking highly motivated and qualified individuals with a PhD in biochemistry, molecular or cell biology, cancer biology or cancer immunology to take over independent research projects on the leukemia microenvironment.
Our previous work showed that Mesenchymal Stem Cells (MSCs) are essential to maintain both normal hematopoietic stem cells and leukemic cells within the endosteal bone marrow niche (Guarnerio et. al., Stem Cell Reports, 2014; Guarnerio et. al., Nat Comm 2018). Future work will elucidate the cancer-sustaining interactions between leukemic cells and MSCs, and will employ spatial single-cell transcriptomic approaches as well as functional genomic screenings to define the molecules at the cross-talk between MSCs and leukemic cells.
* Organize and manage experiments in a dynamic environment
* Design, execute, and critically interpret experiments and present data in a cogent and compelling manner
* Present data at lab meetings, institutional seminars and international conferences
* Under the direction of the PIs, assist in drafting grant proposals, study protocols, and manuscripts
For more information please visit: https://www.cedars-sinai.edu/Research/Research-Labs/Guarnerio-Lab/
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.