The Mellon College of Science (MCS) is home to four departments and many programs and research centers that cross disciplines. We approach scientific problems from fresh angles using creative interdisciplinary approaches while drawing on our departmental strengths in the core sciences. MCS faculty members are nationally and internationally recognized for their research in a variety of fields, including polymer science, cosmology, mathematical finance, and neuroscience.
Applications are invited for a postdoctoral position in Professor Maria Kurnikova's group of theoretical structural biophysics and molecular modeling at Carnegie Mellon University. The applications include molecular dynamics simulations of ionotropic glutamate receptors, RNA/protein interactions and non-heme metal-containing enzymes. The position is funded by grants from NIH and NSF and is available immediately. The initial appointment will be for 1 year with possible extension upon mutual agreement. The salary is generous at NIH level of postdoctoral fellowships, while Pittsburgh is inexpensive and human-friendly place to live.
Recent high-resolution structures of ionotropic glutamate receptors allow us to develop quantitative understanding of these receptors function mechanisms and allosteric regulation. Ionotropic glutamate receptors are the main conduits of excitatory signaling in brain and thus are important for memory, learning and other higher brain function. They are drug targets in a variety of neurodegenerative diseases as well as in ischemic events. We are collaborating with structural biologists and electrophysiologists to model their allosteric functioning mechanisms and drug interactions.
All projects in my group require versatile application of multiple methods of computational chemistry and molecular modeling, including adoption of modern statistical approaches such as Machine Learning and Artificial Intelligence. Opportunities for development of new methodological approaches and software do exist.
The responsibilities will include carrying out research in computer simulations and statistical mechanics on modeling membrane associated receptors and ion channels, as well as other protein and protein/RNA systems. Related tasks will include collaborating in the preparation of reports and journal articles, presenting papers at conferences and workshops, representing the group at meetings and seminars, and supervision of graduate students.
The successful candidate will have strong experience in modern advanced methods of molecular modelling and simulations, statistical mechanics and statistical methods of analysis. He/she will hold a PhD in physics, chemistry, quantitative biology, applied mathematics, or a closely related field, with a strong interest in biological systems. Experience with modeling membrane associated proteins and ion channels is a plus. Knowledge of continuum electrostatics methods, quantum chemistry, force field development, and a strong background in applied math or physics is a plus.
Interested candidate applications consisting of a cover letter outlining skill set, detailed CV, and 2-3 names for reference letters should be submitted through Interfolio.
The evaluation of candidates will begin immediately and continue until the available position is filled.
Carnegie Mellon University is an equal opportunity employer and is committed to increasing the diversity of its community on a range of intellectual and cultural dimensions. Carnegie Mellon welcomes applicants who will contribute to this diversity through their research, teaching, and service, including women, members of minority groups, protected veterans, individuals with disabilities, and others who would contribute in different ways.
Carnegie Mellon University is an Equal Opportunity Employer/Disability/Veteran
Internal Number: 72464
About Carnegie Mellon University
Carnegie Mellon (www.cmu.edu) is a private, internationally ranked research university with programs in areas ranging from science, technology and business, to public policy, the humanities and the arts. More than 12,000 students in the university’s seven schools and colleges benefit from a small student-to-faculty ratio and an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration and innovation. A global university, Carnegie Mellon’s main campus in the United States is in Pittsburgh, Pa. It has campuses in California’s Silicon Valley and Qatar, and programs in Africa, Asia, Australia, Europe and Mexico.