At Boston Children's Hospital, success is measured in patients treated, parents comforted and teams taught. It's in discoveries made, processes perfected, and technology advanced. In major medical breakthroughs and small acts of kindness. And in colleagues who have your back and patients who have your heart. As a teaching hospital of Harvard Medical School, our reach is global and our impact is profound. Join us and discover how your talents can change lives. Yours included.
An exciting opportunity exists in the laboratory of Dr. Elizabeth Engle at Boston Children's Hospital, a cutting edge developmental neuroscience laboratory using emerging techniques in single cell sequencing (scRNA-seq, scATAC-seq, spatial transcriptomics, multi-modal sequencing) to understand the molecular mechanisms of motor neuron diseases, including congenital disorders of eye and facial movement ( http://www.childrenshospital.org/research/labs/engle-laboratory ).
The primary focus of this position is the computational analysis and integration of single cell transcriptomic, genomic and epigenomic datasets. This primarily computational position will also provide the opportunity to translate in silico findings to the bench in order to understand the fundamental biology of neuronal development and disease. This position will work under the direct mentorship of an M.D.-Ph.D. computational biologist and geneticist and also meet regularly with Dr. Engle. Previous RAs in the lab have gone on to M.D, Ph.D., and M.D./Ph.D. programs at Harvard, Johns Hopkins, UC San Diego, University of Pennsylvania, and MIT, as well as successful research positions in the private sector.
The Laboratory Research Assistant I will be responsible for:
Analyzing single cell sequencing data from primary and stem cell-derived neuronal cell types
Learning and implementing machine learning approaches to analyze and integrate transcriptomic, epigenomic, and deeply phenotyped patient whole genome sequence data
Analyzing structural variation from patient whole genome and exome sequencing data
Driving in silico analyses and translating to research at the bench
Collaborating with experimental team members
Periodically presenting research findings in weekly group meeting
Evening and weekend hours will be occasionally required
To qualify, you must have:
BS in Bioinformatics, Computational Biology, Computer Science, Statistics, Mathematics, or related field with an interest in solving biomedical problems, or B.S. in Biology, Chemistry or a closely related field with experience analyzing large and complex datasets
Experience in programming, data management using R or other computer languages/environments
Intrinsic scientific curiosity and enthusiasm for developing new skills and expertise
Ability to think critically, design experiments, and perform independent troubleshooting
Classroom and/or research experience in Biology is preferred but not required
Precise and thorough documentation/organizational skills are a requirement for this position
Two-year commitment requested
Boston Children's Hospital offers competitive compensation and unmatched benefits, including affordable health, vision and dental insurance, generous levels of time off, 403(b) Retirement Savings plan, Pension, Tuition Reimbursement, and discounted rates on T-passes (50% off). Discover your best.
Boston Children's Hospital is an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.
Internal Number: 3032848
About Boston Children's Hospital
Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care. As one of the largest pediatric medical centers in the United States, Children's offers a complete range of health care services for children from birth through 21 years of age.