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Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Infectious Diseases. This position is for the Medical School Campus.
We are looking for an engaged post-doc to study the effects of malnutrition on enteric infections using an intestinal enteroid model. The goal of the project is to understand how malnutrition alters epithelial responses in response to infections, which in turn informs improved vaccine design. The techniques for this project include cell culture, in vitro infection models, RT-PCR, and antibody-based metabolite detection.
The Kuhlmann lab at Washington University in Saint Louis, Missouri, USA, uses translational approaches to correlate observations from field studies with molecular mechanisms of disease. In doing so, we have characterized the global distribution of novel antigens to complement existing enterotoxigenic E. coli (ETEC) vaccine trials (Kuhlmann et al, PLoS NTD, 2019). Additionally, we have utilized genomic and molecular approaches to characterize antigenic diversity from this population. We have also capitalized upon the enteroid system to describe how these antigens interact with host factors, such as blood group antigens on intestinal mucins (Kuhlmann, ASTMH, 2016, Kumar, JCI, 2018). In collaborating with colleagues investigating nutritional interventions to reduce growth stunting, we are examining how specific nutrient deficiencies contribute to diarrheal outcomes, both in vitro and in clinical infections.
The laboratory is part of the Division of Infectious Diseases at Washington University School of Medicine in St Louis (https://infectiousdiseases.wustl.edu). The Division is home to clinical and basic science investigators and promotes translational and clinical research. The laboratory is housed on the Medical Campus together with many other labs studying host-pathogen interactions. We also have access to an enhanced biosafety level 3 laboratory. The work environment is very collaborative and there are many opportunities to work with colleagues in other disciplines. Washington University also has an active Office of Postdoctoral Affairs and is an equal opportunity employer. Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
Ph.D. degree or equivalent in molecular biology, genetics, microbiology, immunology or a similar field.
Published in high-quality peer-reviewed journals.
Ability to guide research projects and maintain detailed records of experimental work.
Good interpersonal skills and willingness to mentor students and technicians.
Excellent speaking, reading and writing skills.
Ph.D. degree in biochemistry, molecular biology or biophysics.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
To apply for this position, please send a cover letter, CV, contact information for three references and one key first author publication directly to email@example.com.
Contact Details F. Matthew Kuhlmann, MD, MSCI Assistant Professor Washington University School of Medicine firstname.lastname@example.org
Internal Applicant Instruction:
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