Summary of Position: The successful Postdoctoral Associate will study the molecular mechanisms of HIV-1 restriction by cellular APOBEC3 proteins and counter-restriction by lentiviral Vif. e.g., JÃ¤ger et al., 2012, Nature; recently reviewed by Harris & Dudley, 2015, Virology. S/he will use molecular biology, cell biology, and virology techniques to investigate this molecular mechanism. S/he will also utilize next generation sequencing (NGS) and informatics approaches.
30% Molecular Biology – designing and constructing novel APOBEC and Vif expression constructs. 30% Virology – working with replication-defective and proficient HIV-1 constructs in cell culture. 15% Cell Biology – use advanced microscopy approaches to visualize APOBEC-cellular and APOBEC-viral interactions in living cells. 15 % Bioinformatics – use NGS and data analysis approaches to understand the scope of HIV mutagenesis by APOBEC enzymes. 10% Administration – training students; drafting manuscripts; presenting data at national and international meetings.
Limited to a period of three years up to five, depending on training needs. The individual may be immediately post-degree or returning for additional training, updating, and retooling. Limited to fields for which post-degree training is necessary for career entry. Post-doctoral associates cannot be appointed on sponsored institutional training grants, sponsored individual fellowship or training awards. Post-doctoral associates are University of Minnesota employees. They are receiving additional training while also performing services for the University, for which they are compensated.
Required Qualifications: PhD degree in virology or related area in 2017 (granted or expected before Dec 31, 2017); 2 first-author publications and co-authored contributions to at least 3 additional publications; extensive experience with cell culture, HIV biology, and advanced fluorescent microscopy approaches.
Preferred Qualifications: Experience with molecular biology, HIV virology, and advanced fluorescent microscopy approaches.
Internal Number: 334649
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