A Drug Discovery I (DDI) employee designs and synthesizes target molecule with minimal to no supervision. In collaboration with other team members, the interpretation of pharmacology and DMPK data in order to design future ligands is necessary. The individual should have excellent written and oral skills and is meticulous at recording and interpreting analytical data (LCMS, NMR, etc.). As VCNDD is a multidisciplinarian organization, collaboration and communication with all members of the drug discovery team is critical. A DDI scientist will mentor younger staff scientists or post-doctoral fellows and has the capability to progress her own work, as well as guide/direct the work of others. Finally, a well-rounded friendly demeanor, including polite and positive attitude is needed.
Every major advance in medicine starts with fundamental discoveries that teach us how living organisms work in both health and disease. These discoveries are made in biomedical sciences laboratories that study life at all levels from the individual molecules that encode heredity to the complex associations of cells that form tissues and organs. Vanderbilt Basic Sciences is a tightly integrated research and education division within the School of Medicine comprising four academic departments, eight interdisciplinary centers, twenty-seven service core facilities, and the Office of Biomedical Research, Education, and Training.
Our team of over 1000 faculty, fellows, students, and staff is making new discoveries every day - discoveries that enrich our understanding of biological processes and provide the foundation for new insights into the causes, prevention, diagnosis, and treatment of human diseases.
Duties and Responsibilities
Design and synthesize target molecules with minimal supervision
Record and interpret analytical data (LCMS, NMR, etc)
Interpret SAR data and incorporate DMPK data into future ligand design
Contribute to research so as to merit serving as author or co-author on research publications
Contribute to a fully functioning discovery team with strong communication skills and in some cases supervise or mentor junior chemists
Be open to collaboration and interaction within the VCNDD team (DMPK, pharmacologists and behavioral scientists) and also other collaborators outside of VCNDD
Implement creative and productive medicinal chemistry practices that progress the project
Capable of multi-tasking several scaffolds within the same project, but also open to handling scale-ups for other projects
Highly motivated individual with the ability to go above and beyond the job description to complete the task
Looks for opportunities to volunteer or help others within the VCNDD (i.e. proactive)
Provides a friendly demeanor, polite, positive attitude and enjoys coming to work
The ideal candidate will possess excellent verbal and written communication skills, perform well in a highly functioning team environment, and be able to independently analyze and interpret spectral and SAR data.
Profile of an Ideal Candidate
Bachelor's degree from an accredited institution of higher education is necessary.
A degree in chemistry, biochemistry, or organic chemistry or similar field from an accredited institution of higher education is highly preferred.
A BS with 5-10 years of experience in Medicinal Chemistry or related filed is required
A MS with 3-5 years of experience in Medicinal Chemistry or related filed is required
A PhD with 0-8 years of experience in Medicinal Chemistry or related filed is required
Experience in a major pharmaceutical company or comparable academic drug discovery institute with a preference for experience in CNS drug discovery medicinal chemistry.
Possess excellent verbal and written communication skills,
Performs well in a highly functioning team environment
Able to independently analyze and interpret spectral and SAR data.
Ability to work in a team-based organization is preferred.
Ability to clearly communicate research results, ideas, and concerns is preferred
Internal Number: 1902122
About Vanderbilt University
Vanderbilt University is a center for scholarly research, informed and creative teaching, and service to the community and society at large. Vanderbilt will uphold the highest standards and be a leader in the quest for new knowledge through scholarship, the dissemination of knowledge through teaching and outreach, and the creative experimentation of ideas and concepts. In pursuit of these goals, Vanderbilt values most highly intellectual freedom that supports open inquiry, equality, compassion, and excellence in all endeavors.