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Application Review Date
The First Review Date for this job is: November 8, 2019.
The California Institute for Quantitative Biosciences (QB3) is one of four Governor Gray Davis Institutes for Science and Innovation established in 2000 to ensure the future of the California economy by promoting research and innovation. QB3 is a cooperative effort between the state of California, private industry, venture capital, and the University of California campuses at Berkeley, San Francisco, and Santa Cruz. QB3 harnesses the quantitative sciences of physics and engineering to unify our understanding of biological systems at all levels of complexity, from atoms and molecules to cells, tissues, and entire living organisms.
QB3 scientists make discoveries that drive the development of technologies, products, and wholly new industries, ensuring that California remains competitive in the 21st century.
QB3's goals are to fuel the California bioeconomy; to support research and training in quantitative biosciences; and to translate academic research into products and services that benefit society.
The Staff Research Associate will, under supervision, contribute to the design, execution, and analysis of experiments. This individual will be a key contributor to a research project focused on identifying new conditions for genome editing of specific cell types, with a focus on enabling accessible therapeutic use of this technology. This position will focus on testing the efficiency of various reagents and conditions in enabling genome editing in mammalian cells in tissue culture. Novel reagent formulations generated by the Wilson lab will be assessed in high-throughput assays performed by the employee. Although the employee will not be responsible for designing the overall research plan, it is imperative that the employee is capable of skillfully adapting to constantly-evolving applications of the techniques used.
Perform high-throughput genome editing assays in tissue culture. These assays may utilize primary cells, human cell lines, or other mammalian cells. Responsibilities include planning practical details of experiments (including calculating reagent dilutions, scheduling of instrumentation, and ensuring that necessary supplies are adequately stocked).
Perform data processing and limited analysis of high-throughput genome editing assays performed in tissue culture. This involves quality control checks (verification that positive and negative controls worked) and establishing correlations between effective editing conditions and the reagents or formulations responsible.
Use lab computers and software to record and compile data; prepare results for presentation.
B.S. in a relevant field (degree must be completed before start date; not required to apply) 1 year of part-time (10 hours per week) or full-time experience in a life-sciences laboratory setting
Basic life-sciences laboratory skills:
Using a pipettor, preparing solutions, diluting reagents, following an established protocol
Working knowledge of MS Office suite (Word, Excel, Powerpoint)
Detail-oriented and well-organized in terms of record-keeping, planning ahead, meeting deadlines
Experience with CRISPR-Cas mediated genome editing
Experience with DNA analysis (PCR, Sanger sequencing, next-generation sequencing, etc.)
Experience with 96-well format high-throughput assays
Experience with mammalian tissue culture
Experience with nucleic acid extraction/purification
Experience with RNA/protein biochemistry
Salary & Benefits
For information on the comprehensive benefits package offered by the University visit:
The University of California was chartered in 1868 and its flagship campus - envisioned as a "City of Learning" - was established at Berkeley, on San Francisco Bay. Today the world's premier public university and a wellspring of innovation, UC Berkeley occupies a 1,232 acre campus with a sylvan 178-acre central core. From this home its academic community makes key contributions to the economic and social well-being of the Bay Area, California, and the nation.