Junior Specialist for Foundation for Angelman Syndrome Therapeutics (FAST) project
The Department of Psychiatry and Behavioral Sciences at the University of California, Davis invites applications for a qualified Junior Specialist with a bachelor's degree in Psychology, Biological Sciences, and/or Neuroscience.
DESCRIPTION The candidate for this position will be involved in a variety of interesting basic science/neuroscience research projects using a rat models of rare genetic disorders of neurodevelopment comorbid with epilepsy. The candidate will participate in the scientific research projects, through a grant funded by the Foundation for Angelman Syndrome Therapeutics (FAST).
The candidate will work under the direction of an academic as part of an interdisciplinary team that measures innovative outcome measures including seizures, electroencephalography, histopathology and a wide variety of in vivo behavioral outcomes following delivery of genetic, pharmacological and stem cell-based therapies in subject animals. The individual holding this position will assist in the overall goals of the lab which are to characterize novel models of deletions, duplications or triplications of the E3 ubiqutin ligase, a genetic cause of autism, intellectual disability and seizure disorder.
Successful candidates will also have 1) experience with breeding, rodent husbandry (with an emphasis on rats over mice) and collecting tissue from animal models, 2) a high level of knowledge of DNA extraction and genotyping by PCR, 3) ability to perform behavioral testing of mouse models for learning and memory and motor abilities, 4) ability to score, and observe seizure events for extended period of time, 5) excellent pharmacological injection skills, 6) skills to harvest rodent brain tissue, and 7) confident and comfortable to perform experiments for which death by seizure is an endpoint.
Other essential qualifications include experience with data collection, data processing, and statistical analysis of experimental data. Computer skills are necessary and include using word processing (for writing experimental methods), data graphics and statistical software. The ideal candidate will have strong interpersonal, communication, and decision-making skills; as well as the ability to work well independently and as part of a team.
General responsibilities include:
*RESEARCH ACTIVITY 75% *
Under the direction of an academic, asses optimized doses of antisense oligonucleotides as gene therapy via various routes of administration
Design experimental groups consisting of dependent variables such as gene (half of the genetic model and half of the control) and treatment conditions
The candidate will need to think creatively about number of Dams to breed, to yield number of offspring to reach a sufficient sample size in the behavior (N=10/sex/genotype/group).
Performing rat behavioral assays, specifically learning and memory assays such as novel object recognition, fear conditioning and touchscreen learning and memory
The candidate must have creative thinking skills on apropos ways of conveying the data when presenting to lab mates familiar with the in-depth research but also to convey data to parents and families of children with the disorder, on the big picture without the nitty gritty. This is a high-level skill that is mastered in academia and will be critical for the candidate to excel at in translational lab
Collecting and Analyzing data and performing statistical analyses in order to contribute figures for PI for grant applications, presentations and publications
PROFESSIONAL COMPETENCE AND ACTIVITY 20%
Participate in weekly meetings to read, discuss and interpret journal articles relevant to the project
Presenting research at family meetings local and/or national conferences
Presentation of their data at a national conference and co-author publications by writing methods and results section text with appropriate statistical analysis
UNIVERSITY AND PUBLIC SERVICE (5%)
Participate in the University by volunteering at special events for children with autism that participate in research studies at the MIND Institute
Engage in recruitment and outreach activities in the community
Promote research being conducted via laboratory social media
Assist with preparations for IACUC inspections
Provide mentorship for undergraduate interns
A Bachelor's degree in Biological Sciences and/or Neuroscience
Experience with breeding, rodent handling and rat husbandry
Ability to work independently
Excellent oral and written communication skills
Ability to set up equipment for experiments and calibrations, according to instructions
Experience in keeping records of results of experiments
Experience with data collection, data processing, and statistical analysis of experimental data
Computer skills including using word processing (for writing experimental methods), data graphics and statistical software
The ideal candidate will have strong interpersonal, communication, and decision-making skills; as well as the ability to work well independently and as part of a team
Ability to perform behavioral testing of mice on a broad range of assays, following detailed instructions
Ability to score videos for behavioral events for an extended period of time
Excellent pharmacological injection skills
SALARY RANGE: Step 1 - $39,500 annual, or Step 2 - $42,100 annual, commensurate with qualifications and experience.
TERM OF APPOINTMENT: This is a one-to-two-year appointment at 100% effort.
TO APPLY: For full consideration, applications must be received by 10/28/2019; however, the position will remain open until filled through 6/30/2020 or until filled. To apply, please go to the following link: https://recruit.ucdavis.edu/JPF03197
Applicants should submit cover letter, CV or resume, and contact information for at least 3 references. Documents/materials must be submitted as PDF files.
The University of California, Davis commits to inclusion excellence by advancing equity, diversity and inclusion in all that we do. We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, and individuals with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community.
Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain UCSC positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check. More information is available http://www.uscis.gov/e-verify.
UC Davis is a smoke & tobacco-free campus (http://breathefree.ucdavis.edu/). If you need accommodation due to a disability, please contact the recruiting department.
UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we’ve been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society.Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive.