Post-doctoral researchers are invited to join a dynamic team investigating the role of microglial cells in neuroinflammation at the University of Pennsylvania. The first position focuses on enhancing autophagy and clearance of waste by microglial and epithelial cells by modulating lysosomal function. The second position probes the role of the P2X7 receptor and the NLRP3 inflammasome on microglial cells in cytokine release, neuroinflammation and neuronal death. Both positions will use mechanistic understanding to develop novel treatments to prevent neuroinflammation and evaluate their ability to preserve neural function. Treatment strategies include small molecules, FDA-approved drugs, nanoparticles and gene therapy. Successful candidates are encouraged to work together with the PI to advance the research project. Responsibilities include experimental design, data analysis, manuscript writing, collection and preparation of samples, live-cell imaging experiments, molecular analysis and measurements of efficacy. Researchers are encouraged to present at national and international scientific conferences and helped to apply for funding.
Candidates should expect to receive their PhD within 3-6 months or have obtained one within the last 2 years in the fields of molecular biology, cell biology, neuroscience, or a related biomedical science field. A strong background in molecular biology and mouse model design is required, with experience using gene therapy, CRISPR approaches, neuro-glial interactions, live-cell imaging, patch clamping, drug development and/or nanoparticles an advantage. The successful candidate will possesses the ability to work both independently as well as in a collaborative environment and should have documented success in research including publications in international journals on relevant topics.
Internal Number: 015537
About University of Pennsylvania
University of Pennsylvania dates its founding to 1740. Academic life at Penn is unparalleled, with 100 countries and every U.S. state represented in one of the Ivy League’s most diverse student bodies. Consistently ranked among the top 10 universities in the country, Penn enrolls 10,000 undergraduate students and welcomes an additional 10,000 students to our world-renowned graduate and professional schools. The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania does not discriminate on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class status in the administration of its admissions, financial aid, educational or athletic programs, or other University-administered programs or in its employment practices.