Principle Investigator, Dr. Megan Hitchins, is a member of the faculty of Biomedical Sciences at Cedars-Sinai Medical Center and is situated with the Center for Bioinformatics and Functional Genomics (BFG). The BFG brings together teams specializing in bioinformatics and computational biology, functional analysis of the genome and epigenome coupled with next generation sequencing, epigenetic profiling, and genome editing, to provide a complete pipeline for identifying the functional consequences of genetic and epigenetic variation in cancer risk, subtypes, and outcomes. Dr. Hitchins' group focuses in particular on the role of genetic and epigenetic variants in high-risk cancers, and on DNA methylation markers of cancer, as applied to the detection of circulating tumor DNAs.
Dr. Hitchins is looking for a Postdoctoral Scientist to join the BFG to investigate methylation markers specific to cancer that may be exploited as biomarkers for cancer risk stratification, detection, diagnosis, prediction of treatment outcomes, and monitoring of treatment outcomes. The ideal candidate we are searching for will have wet-lab training in genetic, transcriptional and/or methylation analysis methods that include next generation sequencing based assays, methylation analysis techniques, and solid statistical analysis skills. The position requires a solid understanding of the molecular biology (genetics, epigenetics and gene regulation) underlying cancer.
As an appointed Postdoc, you will work with Dr. Hitchins on germline genetic variation, RNA expression, and DNA methylation associated with cancer phenotypes. You will be supported by a Research Associate/Laboratory Manager and work within a highly integrated and multi-disciplinary group comprising senior and junior post-doctoral scientists, research technicians, clinical fellows and graduate students. You will be expected to conduct wet-lab research and statistical analyses of data (both directed and independent) under the mentorship of Dr. Megan Hitchins, submit and publish papers and posters, and make oral presentations. This post-holder must be well organized and be able to demonstrate written and oral presentation skills.
Essential job duties and responsibilities:
Lead research project(s) in the genomics and epigenomics of cancer that form part of the research program under the mentorship of the Principal Investigator. This will include the undertaking of intellectual, technical (wet-lab), and analytical aspects of the project(s)
Draft manuscripts for publication and author or co-author
Contribute to the drafting of grant proposals
Attend, contribute to, and present at laboratory group meetings and departmental meetings
Present research findings at national and international conferences
Provide miscellaneous research support (ad hoc data analysis, hypothesis development, programming, troubleshooting, etc.)
Lead and train incoming Graduates Students, Research Fellows, lower level Research Associates, and other related support staff and may be requested by Pl to take on specific day-to-day supervisory activities
Comply with all safety standards and procedures
Assist with the establishment and maintenance of IRB proposals and protocols relating to projects in the laboratory
Assist with the maintenance of database and accompanying biorepository
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.