1) Work on research projects focusing on the molecular mechanisms regulating intestinal transport of oxalate, with special emphasis on SLC26A6 (an anion exchanger with an essential role in intestinal oxalate secretion), by different neuro-hormonal factors and gut microbiome, and how this regulation might pertain to the risk of hyperoxalemia, hyperoxaluria and calcium oxalate kidney stone disease.
2) An important ongoing project is about evaluating the therapeutic impact of Oxalobacter formigenes-derived small peptides (which were optimized through structural modifications and were thus made resistant to proteolytic degradation) as potential novel therapeutics agents for hyperoxalemia, hyperoxaluria, and related kidney stone disease.
3) The peptides (including peptide-loaded nanoparticles for sustained and localized colonic delivery of these peptides) will be administered rectally as enemas, and if an in vivo effect is seen by lowering plasma and urine oxalate levels, then an oral formulation will be developed.
4) Other ongoing projects include elucidating the pathogenesis of obesity - and IBD-associated hyperoxauria and their relevance to calcium oxalate kidney stone disease. 5) Using a diversity of cultured mammalian cells and whole animals, ongoing research utilizes a variety of contemporary techniques, including biochemical techniques (Western blotting, immunoprecipitaion, etc.), standard molecular biology procedures (cloning, q-pcr, site-directed mutagenesis, etc.), microscopic & genomic approaches, protein and peptide biochemistry (including purification/column chromatography and MASS/SPECT, stability assay using LC-MS to ensure that the optimized peptides are resistant to proteolytic degradation), as well as flux studies in cells and intestinal tissues mounted in Ussing chambers.
1) Knowledge in relevant scientific field.
2) Knowledge of research techniques or methods.
3) Knowledge of regulatory policies and procedures.
4) Analytical skills.
5) Problem-solving skills.
6) Attention to detail.
7) Organizational skills.
8) Verbal and written communication skills.
9) Ability to work independently and as part of a team.
10) Knowledge of Microsoft Office.
1) Bachelorâ™s degree in Biological Sciences or related field
1)Previous research experience with basic molecular biology, biochemical techniques, and animal-related work (including oral gavage, rectal enemas, etc.)
2) Cover letter
NOTE: When applying, all required documents MUST be uploaded under the Resume/CV section of the application.
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