Topic: Transient Receptor Potential (TRP) and mechanosentive Piezo ion channels. We are interested in the mechanism of the regulation of these channels, and their roles in biological processes such as pain, temperature and mechanosensation.
Methods: The successful applicant will apply state-of-the-art molecular, electrophysiological and fluorescence-based tools to investigate the regulation of TRP and/or Piezo channels. Candidates with experience in patch clamp electrophysiology are preferred. Experience in Ca2+imaging, molecular biology and pain related animal behavior is also appreciated.
Liu, L., Yudin, Y., Nagwekar, J., Kang, C., Shirokova, N. & Rohacs, T. Gaq Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation. Journal of Neuroscience 39, 6067-6080, (2019).
Yudin Y, Rohacs T. The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels. Br J Pharmacol. 176(17):3110-3125 (2019)
Badheka, D., Yudin, Y., Borbiro, I., Hartle, C. M., Yazici, A., Mirshahi, T. & Rohacs, T. Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits. Elife 6, e26147, (2017).
Borbiro, I., Badheka, D. & Rohacs, T. Activation of TRPV1 channels inhibit mechanosensitive Piezo channel activity by depleting membrane phosphoinositides. Science Signaling 8, ra15, (2015).
How to apply: e-mail CV and the names of three references to: firstname.lastname@example.org
The position requires a Ph.D. degree and relevant research experience. Candidates with experience in patch clamp electrophysiology are preferred. Experience in Ca2+imaging, molecular biology and pain related animal behavior is also appreciated.
Additional Salary Information: Standard NIH Postdoc salary depending experience
Internal Number: 001
About Rutgers - New Jersey Medical School
The laboratory of Dr Tibor Rohacs is located at Rutgers New Jersey Medical School, Newark, NJ. We study temperature sensitive Transient Receptor Potential ion channels, as well as mechanically activated Piezo ion channels. We employ electrophysiology (patch clamp), fluorescence imaging, molecular biology and mouse behavior and genetics to study these channels in the context of somatosensory physiology and pain. Visit my lab's website at https://rohacslab.org for more information.