Postdoctoral fellow position available immediately for a US citizen or US permanent resident to study novel signal transduction pathways downstream of insulin or IGF1 in adult skeletal muscle. Project to be carried out in the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine under the co-direction of Dr. A. Kontrogianni-Konstantantopoulos and Dr. Martin Schneider. Insulin/IGF1 signaling pathways will be monitored in isolated living adult muscle fibers maintained in cell culture and studied by live cell time lapse fluorescence confocal microscopic imaging using fluorescent fusion protein constructs of various signaling molecules that alter their subcellular distribution during the signal transduction events. Parallel studies will use biochemical techniques to monitor levels and phosphorylation status of enzymes in the signal transduction pathways. Molecular modification of the fluorescent fusion proteins will provide insight into the molecular bases of the various steps in the signal transduction pathway. These studies will provide important insights into novel pathways and molecular regulatory mechanisms underlying insulin and IGF1signaling for the control of both adult skeletal muscle mass and glucose metabolism in adult muscle, with additional possible relevance to similarities and differences with other insulin and/or IGF1 responsive tissues and to disruption of normal signaling in diabetes, muscle wasting and possibly other muscle disease conditions.
Successful candidate should have experience in cell culture, imaging and/or standard biochemical and molecular biological techniques. The postdoctoral fellow will be expected to be current in the literature in the field, plan and conduct experiments, interpret data, and publish results. Applicants must possess a PhD degree, should have excellent oral and written communication skills, and display initiative as well as independence. The successful candidate will have the opportunity to attend and present his/her work in national and international meetings, be part of a muscle-interest group, participate in collaborative projects, and be trained in successful grant writing skills.
Salary is based on NIH salary levels. Please send a brief statement of previous experience (1/2 page max), curriculum vitae, and the names and contact information of three references to:
UMB is an equal opportunity/affirmative action employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law or policy.
Successful candidate should have experience in cell culture, imaging and/or standard biochemical and molecular biological techniques.
Job: Postdoctoral Fellows
Organization: School of Medicine - Basic Science Departments
Job Posting: Sep 25, 2019
Internal Number: 135001
About University of Maryland, Baltimore
The University of Maryland, Baltimore (UMB) is the State's public health, law and human services university devoted to excellence in professional and graduate education, research, patient care, and public service. As a diverse community of outstanding faculty, staff and students, and using state-of-the-art technological support, we educate leaders in health care delivery, biomedical science, global health, social work and the law. We emphasize interdisciplinary education and research in an atmosphere that explicitly values civility, diversity, collaboration, teamwork and accountability. By conducting internationally recognized research to cure disease and to improve the health, social functioning and just treatment of the people we serve, we foster economic development in the City, State, and nation. We are committed to ensuring that the knowledge we generate provides maximum benefit to society and directly enhances our various communities.