The Pravetoni lab at the University of Minnesota Medical School is seeking a scientist for development of vaccines and antibody-based therapeutics to counteract opioid use disorders and overdoses. Our unique multidisciplinary research program integrates rational vaccine design, immunomodulators, formulation/delivery platforms, pre-clinical models, analysis of B and T cell lymphocyte repertoire, GLP/GMP studies to support regulatory approval and clinical evaluation, and ad hoc industry collaborations. Our team is currently planning Phase I clinical trials of vaccines targeting various opioids. Strategies and platforms will be applied to development of vaccines or antibodies against biological or chemical threats. We are seeking a scientist to qualify vaccine and monoclonal antibody (mAb) lots by various assays including ELISA, BCA assay, Protein G chromatography, LAL assay for endotoxin content, SDS-PAGE.
70% Solve complex and varied problems related to on-going research projects. Independently perform the following experimental procedures: ELISA-, BCA assay, Protein G chromatography, LAL assay for endotoxin content, SDS-PAGE. Coupling chemistry, purification, MALDI-TOF or DLS. Create data collection tools.
20% Exclusively responsible for immunizing mice and rats, collect tissue. Assist with in vivo assay.
10% Develop standard operating procedures, assist with Master Batch Records, review documents related to vaccine batches.
Required Qualifications (must be mentioned on application/resume) Master’s Degree and two years of related experience or BS degree in Biological Sciences and four years of related experience. Protein expression or antibody purification experience.
Preferred Qualifications: ELISA, BCA assay, Protein G chromatography, LAL assay for endotoxin content, SDS-PAGE. Coupling chemistry, to conjugate haptens to carriers. purification (TFF).
Internal Number: 333007
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.