This position will be in a laboratory in which the primary focus is on studying the genetics of pediatric cancer, including sarcomas and brain tumors, to identify novel therapeutic targets to better treat pediatric cancer patients. The Moriarity lab uses animal models and comparative genomics approaches to identify new candidate cancer genes. Once identified, candidate genes are functionally studied in human cancer and immortalized cell lines using cutting edge technologies, such as targeted nucleases. The primary targeted nucleases used in the Moriarity lab are the CRISPR/Cas9 and Transcriptional Activator-Like Effector (TALEN) systems, which are used to knockout genes, induce targeted sequence changes, activate and/or repress endogenous gene expression.
Responsibilities: Conduct and analyze data from Experiments (90%) -Genome editing of iPSCs -Assess rates of editing and carryout functional assays -Breeding and genotyping mice
Routine lab maintenance (10%) Materials acquisition and laboratory organization as necessary
***All required qualifications must be documented on application materials***
Required Qualifications: *BA/BS and 1 year of related experience of equivalent combination of education and work experience to total 5 years
Preferred Qualifications * 1 year of experience using Crispr/Cas9 is strongly preferred * 1 year of experience using TALEN systems is strongly preferred
Internal Number: 332444
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