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Posted Job Title
Resource Technologist B
Job Profile Title
Resource Technologist B
Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the go-to organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide.
The Vector Core is looking to add a Resource Technologist B (RTB) to the Research Quality Control (QC) group. As an RTB, you will support research studies as well as IND-enabling studies and human phase I & II clinical trials, conducting and qualifying quality control assays to determine the quality, quantity, and potency of viral-based vectors, while following established protocols or standard operating procedures. You will also participate in data analysis, database entry, and completion of batch record forms. In this role, you will report to the Director of Pre-clinical QC and interact closely with the GLP QC, assay development and vector manufacturing groups at GTP.
The assays and techniques that are frequently used in genome titer determination, infectivity, biodistribution, in vivo potency assays, endotoxin, purity assays and rcAAV are mammalian cell/tissue Culture, qPCR, dd-PCR, cell based potency assays, RNA expression, viral clearance, ELISA, western blots, and gel electrophoresis.
Bachelor's of Science in Biology, Biochemistry, Immunology, Virology, or a related field and 3 to 5 years of relevant laboratory experience, or an equivalent combination of education and experience, are required
Experience conducting non-PCR based assays, such as western analysis and potency assays, is a plus
Flexibility to work in a research and GLP laboratory environment is preferred.
Ability to work as part of a team
Excellent oral/written communication skills required
Job Location - City, State
Department / School
Perelman School of Medicine
$42,953.00 - $77,315.00
Affirmative Action Statement Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.
Special Requirements Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Internal Number: JR00005096
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.