A NIH-funded Postdoctoral Research Associate position is available in the laboratory of Dr. Peng Jiang in the Department of Cell Biology and Neuroscience, Rutgers Univeristy New Brunswick. The research theme of the laboratory is on investigating cellular and molecular basis of human neural development and pathogenesis of neurological disease utilizing human induced pluripotent stem cells (hiPSCs). We focus on (i) establishing patient-derived and disease-specific hiPSCs; (ii) Modeling neurodevelopmental/neurodegenerative disorders (e.g. Down's syndrome and Alzheimer's disease) and finding new therapeutics using hiPSC-based in vitro brain organoid and in vivo human chimeric mouse brain models; and (iii) differentiating hiPSCs towards neural lineages for regenerative medicine and developing hiPSC-based cell therapies utilizing animal models of human CNS injuries (e.g. brain hypoxic-ischemic injury). We have been using a combination of multidisciplinary techniques in our research, including stem cell reprogramming, electrophysiology/patch-clamp recording, imaging techniques, molecular/cell biology, biochemistry, pharmacology, RNA-sequencing techniques, transgenic and surgically induced animal models, and animal behavioral testing.
For more information about our research, please see our recent publications in Nature Communications (PMID: 23880652 & 25034944), Nature Protocols (PMID: 21527921), Trends in Molecular Medicine (PMID: 26443123), Cell Reports (PMID: 27134175), ACS applied materials & interfaces (PMID: 29897225), Stem Cells (PMID: 23940003), and Journal of Clinical Investigation Insight (PMID: 27882348) https://www.sas.rutgers.edu/cms/cbn/peng-jiang-lab/353-publications.
The postdoctoral trainees in the lab are expected to independently design and execute incisive experiments and interpret results, present scientific work for internal or external communication, and to prepare manuscripts and author papers in high profile journals in areas relevant to the research directions.
Minimum Education and Experience:
We are looking for individuals who are interested in working on differentiation of human pluripotent stem cells to neural cells or tissues, and application of these stem cell technologies to the development of in vitro and in vivo models for better understanding human brain development and disease and for drug screening/discovery. Candidates should have a good publication record and a Ph.D. in neurobiology, developmental neuroscience, stem cell biology or related fields. Researchers who are experienced in human pluripotent stem cell culture and differentiation, organoid culture, and glial cell culture are encouraged to apply. Additional experience with imaging techniques, viral preparation and infection, intracerebral cell transplantation, and animal work are desired.
Posting Number: 18FA0368
Location: Busch (RU-New Brunswick)
Internal Number: 71287
About Rutgers University
Rutgers, The State University of New Jersey, is a leading national public research university and the state's preeminent, comprehensive public institution of higher education. Rutgers is dedicated to teaching that meets the highest standards of excellence; to conducting research that breaks new ground; and to turning knowledge into solutions for local, national, and global communities. As it was at our founding in 1766, the heart of our mission is preparing students to become productive members of society and good citizens of the world. Rutgers teaches across the full educational spectrum: preschool to precollege; undergraduate to graduate and postdoctoral; and continuing education for professional and personal advancement. Rutgers is New Jersey's land-grant institution and one of the nation's foremost research universities, and as such, we educate, make discoveries, serve as an engine of economic growth, and generate ideas for improving people's lives.