Our laboratory investigates the role of metabolism and inflammation in breast cancer progression. Breast cancer patients with obesity and Type 2 diabetes tend to develop metastases earlier, and our data suggest that abnormal immune function and metabolism in these patients is a major contributing factor. We conduct multidisciplinary research in a strong, team-based environment to understand these mechanisms and reduce breast cancer mortality. In particular, triple-negative breast cancer is an aggressive subtype and difficult to treat, because such patients do not respond to hormone therapy and show worse outcomes after conventional chemotherapy. Thus the problem is urgent. Nevertheless, new insights from our lab provide clues for how to design and improve immunotherapy for these patients.
This full time position requires a basic understanding and application of scientific techniques in the life sciences. Your role will be to support tissue culture experiments, perform transfections, conduct ELISA validation of targets and controls with isotype antibodies, isolate RNA or DNA, and perform PCR. A focus of your effort will be to assist investigators with an animal model of breast cancer metastasis. You will also assist in isolation and purification of lymphocytes from human peripheral blood and tumor samples from patients. Routine jobs in the laboratory also include ordering of reagents and supplies from commercial vendors, preparing basic solutions and straightforward procedures as assigned (e.g. pipetting), calibrating instruments and acting as the biosafety and chemical safety officer. Other activities include preparing lab reagents, chemicals and equipment, performing independent literature searches, preparing and running samples on a flow cytometer, attending our research meetings and presenting your data.
Demonstrated competence in basic research techniques and methodologies: Familiarity with flow cytometry, basic molecular biology techniques, ability to work with mice.
Ability to work independently and as a team member
Good communication skills
Working knowledge of research protocols
Ability to perform multiple tasks independently
Bachelor's degree and 1-3 years' experience required
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law. We are a VEVRAA Federal Contractor.
Internal Number: 8964
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