Dr. Keith Syson Chan's laboratory is seeking an early-stage postdoctoral scientist with proficient skills in molecular biology to investigate a novel outside-in-collagen receptor signaling and its transcriptional modulation of master regulators in collective cell migration, building on strong unpublished molecular regulation data and ChIP seq findings. The candidate must have a minimum of one first-author paper and should be a recent graduate (within one year). Candidates studying signaling transduction using CRISPR/Cas-mediated site-specific mutagenesis and domain swapping expertise will be highly preferred, experience in bioinformatic analysis of ChIP-seq results will be a plus. The candidate w ill be encouraged to venture into the broader roles of this signaling pathway in regulating the metastatic cascade, using many established in vivo models in our laboratory.
Examples of the significant contributions in the field made by Dr. Chan's lab are found in the following publications:
The postdoctoral scientist will w ork independently but in close cooperation and in consultation with the Principal Investigator and other Research Scientist s. The postdoctoral scientist will perform routine and complex laboratory procedures throughout training period and m ay develop, adapt, and implement new research techniques and protocols. The postdoctoral scientist will be r esponsible for designing experiments, and assembeling data. He/she will a nalyze and interpret data , assist in preparation of grant proposals , and participate in publications and presentations as author or co-author. For eager postdoctoral scientists interested in applying for grant funding, mentorship will be provided, but there is no requirement for generating grant funding in this position
Primary Duties and Responsibilities
May assist in preparation of grant proposals, but is not responsible for generating grant funds.
Responsible for the designe of experiments in cooperation with the mentor.
Responsible for compiling figures and text for the submission of publications and presentations as author or co-author.
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the mentor.
May develop, adapt, and implement new research techniques and protocols.
Performs routine and complex laboratory procedures throughout training period.
Operates and maintains equipment and instruments.
Department and/or Unit Specific Responsibilities
Characterizes a newly-discovered metastatic niche and its modulation of lung colonization.
Builds on existing preliminary studies (RNA seq profiling of tumor and niche cells), tools and established metastatic models.
Investigates cancer stem cells and their interaction of the immune and stromal microenvironments.
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research... and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major teaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.