Research projects will involve studies in B-cell malignancies (e.g., chronic lymphocytic leukemia; CLL) including disease biology, tumor microenvironment (TME) interactions, immune (dys)function as well as pre-clinical evaluation of novel targeted therapies such as novel small molecule inhibitors targeting B-cell specific kinases and the bromodomain and extra-terminal (BET) family proteins. Pre-clinical evaluations of these novel therapeutics in primary cells, cell lines and/or mouse models will include evaluating their therapeutic benefits, their ability to modulate TME interactions and immune function in CLL, and potential resistance mechanism. Interested candidates should provide us with most recent CV (including contact information for 3 referees) and statement of research interests
Candidates should have PhD in cancer biology, immunology or related field. Basic and advanced molecular biology techniques (e.g., PAGE, WB, ELISA, molecular cloning, plasmid vectors engineering, transfection, and extraction of RNA,DNA and protein etc) flow cytometry (experimental/panel design and analysis) and sterile cell culture techniques including primary cell isolation.
Background in hematological malignancies as well as experience working with mouse models to evaluate novel therapies and cancer immunology is highly preferred. The candidate should be extremely motivated with excellent English skills both oral and written. For further details on the nature of our lab’s research, these articles are recommended; PMID: 29386193, PMID: 25001469, PMID: 24413321 and PMC5320964. To read more about the lab, visit https://unmc.edu/eppley/about/faculty/elgamal.html Other qualifications are: Use of bioinformatic tools for analysis and interpretation of omics data (e.g. RNA-seq, ATAC-seq, proteomics) and genome editing
A vital enterprise in the nation’s heartland, the University of Nebraska Medical Center has its eye on improving the future of health care in Nebraska and beyond. As Nebraska’s only public academic health sciences center, UNMC is committed to the education of a 21st century health care work force, to finding cures and treatments for devastating diseases, to providing the best care for patients, and to serving our state and its communities through award-winning outreach. UNMC also is committed to embracing the richness of diversity, and is a major economic engine for the state of Nebraska.Led by Chancellor Jeffrey P. Gold, M.D., UNMC has six colleges and two institutes, serving about 3,700 students in more than two dozen programs. Our primary care program was recently ranked fourth in the nation by U.S. News & World Report, and our physician assistant program was ranked ninth. The university’s physical therapy, pharmacy and public health programs also are ranked among the top in the country. ... Major Units: College of Medicine, College of Nursing, College of Pharmacy, College of Dentistry, College of Public Health, Graduate College, College of Allied Health Professions, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, Munroe-Meyer Institute, Stanley M. Truhlsen Eye Institute.