Affiliated with the University of Pittsburgh School of Medicine
Instructor Position for Computational Genomics, Bioinformatics, or Molecular Cancer Biology
Wang Laboratory of the UPMC Hillman Cancer Center seeks applications for a full time Research Instructor faculty position in the Department of Pathology, University of Pittsburgh. The individual will be working on our integrative computational genomics initiatives aimed at identifying pathological genetic aberrations, predictive biomarkers, and therapeutic targets from cancer genomics datasets, as well as developing novel bioinformatics tools and models to predict therapeutic responses of targeted therapies and immunotherapies. The candidate must hold a Ph.D. degree in the Biomedical Sciences. Preference will be given to highly motivated candidates with an outstanding publication record in cancer research, and those with established expertise in computational genomics, bioinformatics and biostatistics, or molecular cancer biology. The candidate may choose to work on dry or wet laboratory projects or both.
The research topics for computational genomics and translational bioinformatics will include: 1) Develop novel mathematical, statistical, and artificial intelligence (Al) models, as well as bioinformatics tools, to predict therapeutic outcome of targeted therapies and immunotherapies based on deep sequencing and single cell sequencing datasets. 2) Perform integrative analysis of deep-sequencing datasets and integrate these datasets with drug sensitivity datasets to identify predictive biomarkers for targeted therapies. 3) Catalog pathological genetic alterations in cancer through integrative analysis of whole-genome and transcriptome sequencing datasets.
The research topics for molecular cancer biology will include studying recurrent genomic rearrangements, predictive biomarkers, and targeted agents in more aggressive forms of breast cancers. The primary responsibilities will include experimental validation of newly discovered cancer targets and predictive biomarkers, characterize their molecular basis, elucidating their clinical significance using patient samples, confirming their role in tumor initiation, progression, and therapeutic resistance in vitro and in vivo, pinpointing their action mechanisms, and exploring potential clinical applications.
Wang laboratory is a computational genomics and translational cancer research lab at UPMC Hillman Cancer Center, Department of Pathology, University of Pittsburgh. The long-term goal of this lab is to apply a multiple disciplinary approach inclusive of computational genomics, bioinformatics, molecular cancer biology, and translational studies to identify viable cancer targets and predictive biomarkers, as well as developing the bioinformatics tools for genomics-based cancer precision medicine. For more information, please visit http://www.cagenome.org/lab .
To apply, please send your CV, cover letter, and the contact information of 3 referees to:
Xiaosong Wang, M.D., Ph.D.
Associate Professor of Pathology and Biomedical Informatics
UPMC Hillman Cancer Center
Review of applications will begin immediately until these positions are filled. The University of Pittsburgh offers a comprehensive salary program and excellent benefits in a smoke and drug free workplace. University of Pittsburgh School of Medicine is an Affirmative Action/Equal Opportunity Employer and encourages applications from under-represented groups. EEO/AA/M/F/Vets/Disabled
Please refer to job description. The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets
Assignment Category: Fulltime-Regular
Required Attachments: Other (see posting for additional details)
Internal Number: 19004559
About University of Pittsburgh
Founded in 1787, the same year the U.S. Constitution was signed, the University of Pittsburgh is one of the oldest institutions of higher education in the United States. One of three state-related research universities in Pennsylvania, Pitt is a member of the Association of American Universities (AAU), which comprises 62 preeminent doctorate-granting research institutions in North America.Pitt faculty members have expanded knowledge in the humanities and sciences, earning such prestigious honors as the National Medal of Science, the MacArthur Foundation’s “genius” grant, the Lasker-DeBakey Clinical Medical Research Award, and election to the National Academy of Sciences and the Institute of Medicine. Pitt scientists have defeated polio, unlocked the secrets of DNA, lead the world in organ transplantation, and pioneered TV and heavier-than-air flight, among numerous other accomplishments.Pitt students have earned Rhodes, Goldwater, Marshall, and Truman Scholarships, among other highly competitive national and international scholarships.Alumni have pioneered MRI and TV, won Nobel and Pulitzer Prizes, led corporations and universities, served in government and the military, conquered Hollywood and The New York Times bestsellers list, and won Super Bowls and NBA championships.