Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Oncology. This position is for the Medical School Campus.
The Bose laboratory focuses on the genomics of breast cancer and we use cancer organoid methods to functionally study oncogenic mutations and perform drug testing. The work of Prof. Hans Clevers provides a breakthrough to culture primary human cancer samples in the laboratory, see Sachs et al., Cell 2018 Jan 11;172(1-2):373-386. We are applying these techniques to study the HER2 receptor tyrosine kinase in breast cancer. We identified activating mutations in HER2 and have proven in both preclinical publications and a human clinical trial that inhibiting HER2 mutations is an effective treatment for metastatic breast cancer patients.
Candidates must have strong expertise with mammalian tissue culture.
We are specifically looking for someone with expertise in one of the following areas:
Cell separation techniques, such as FACS based Cell Sorting or other methods.
Bose R*, Kavuri SM, Searleman AC, Shen W, Shen D, Koboldt DC, Monsey J, Goel N, Aronson AB, Li S, Ma CX, Ding L, Mardis ER, and Ellis MJ*. Activating HER2 mutations in HER2 gene amplification negative breast cancer. Cancer Discovery, 3(2):224-37 (2013). *Corresponding authors.
Kavuri SM, Jain N, Galimi F, Cottino F, Leto SM, Migliardi G, Searleman AC, Shen W, Monsey J, Trusolino L, Jacobs SA, Bertotti A, Bose R. HER2 activating mutations are targets for colorectal cancer treatment. Cancer Discovery. 5(8):832-41 (2015).
Information about Washington University:
Consistently ranked among the top 10 US medical schools, Washington University School of Medicine offers a highly interactive and stimulating academic environment for scientists in training. The Siteman Cancer Center at Washington University is a NCI-designated Comprehensive Cancer Center. We are located in the heart of the Central West End, a vibrant St. Louis neighborhood adjacent to major cultural institutions and one of the country’s largest urban parks. We offer competitive salary and benefit packages. Links for more information on Washington University and St. Louis.
Ph.D. in Cancer Biology, Cell Biology, Molecular Biology, or related field.
To Apply: Please send CV and names of 3 references to Maureen Highkin at email@example.com.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.