The Merchant lab applies cutting edge immune profiling modalities to study the immune system in patients with hematologic malignancies.We are looking for an immunologist with an interest in translational medicine to lead laboratory studies related to clinical trials that are currently in progress and to help design appropriate laboratory correlates for clinical trials that are being planned. In particular, we are interested in understanding the function of NK and T cell biology in the context of allogeneic bone marrow transplant, adoptive cell transfer, CART cells, bi-specific immune cell engagers (BiTE), and oncolytic virus therapy.Our lab runs the imaging mass cytometry/CyTOF core facility at Cedars-Sinai.Imaging mass cytometry allows for highly multiplexed (35+ markers) imaging of immune and tumor cells, with spatial information and subcellular resolution.Imaging mass cytometry can be applied to all tissue types including cell lines, organoid, frozen section and FFPE fixed archival tissue.The lab also has projects that test immune therapies in xenograft models of human tumor and transgenic mouse models that would offer opportunities to perform mechanistic studies related to tumor immunology.Collaborations with other investigators at Cedars-Sinai allows access to single cell RNAseq, mass spec proteomics, and metabolic studies of immune cells.
Primary Duties and Responsibilities:
Designs and performs experiments. Will keep appropriate experimental records and documentation and analyze the results with the Principal Investigator.
Will assist in preparation of grant proposals, but is not responsible for generating grant funds.Will be encouraged to apply for fellowships as part of career development
Will participate in publications and presentations as author or co-author.
Will develop, adapt, and implement new research techniques and protocols.
May develop, adapt, and implement new research techniques and protocols.
Analyzes, interprets, summarizes and compiles data.
Performs routine and complex laboratory procedures throughout training period.
Since its beginning in 1902, Cedars-Sinai has evolved to meet the healthcare needs of one of the most diverse regions in the nation, continually setting new standards in quality and innovation in patient care, research, teaching and community service. Today, Cedars-Sinai is widely known for its national leadership in transforming healthcare for the benefit of patients.Cedars-Sinai is one of the largest nonprofit academic medical centers in the U.S. with 886 licensed beds, 2,100 physicians, 2,800 nurses and thousands of other healthcare professionals and staff. Clinical programs range from primary care for preventing, diagnosing and treating common conditions to specialized treatments for rare, complex and advanced illnesses. In addition, Cedars-Sinai serves the community through its Medical Network, which includes the highly rated Cedars-Sinai Medical Group and Cedars-Sinai Health Associates. Cedars-Sinai has consistently been named one of America’s Best Hospitals by U.S. News & World Report, has received the National Research Corporation’s Consumer Choice Award 18 years in a row for providing the highest quality medical care in Los Angeles, and has the longest running Magnet desig...nation for nursing excellence in California. Cedars-Sinai is a leader in the clinical care and research of heart disease, cancer and brain disorders, among other areas. Pioneering research achievements include using cardiac stem cells to repair damaged hearts, developing minimally invasive surgical techniques and discovering new types of drugs to target cancer more precisely. Cedars-Sinai also impacts the future of healthcare through education programs that encompass everything from highly competitive medical residency and fellowship programs to a biomedical science and translational medicine PhD program, advanced training for nurses and educational opportunities for allied health professionals. Most notably, Cedars-Sinai demonstrates a longstanding commitment to strengthening the Los Angeles community through wide-ranging programs that improve the health of its most vulnerable residents.