We are seeking a talented and highly motivated chemist with a strong background in synthetic organic chemistry and familiarity with the application of DNA encoded chemistry to join our Library Discovery team.
You will join a group with two objectives: 1) Design and synthesize DNA encoded libraries and 2) Utilize these libraries to identify novel chemical matter with the potential to modulate the activity of UPS targets.
You will have demonstrated experience in synthetic organic chemistry and analytical methods. Experience with DNA encoded library synthesis, parallel reaction chemistry, split/pool methods, aqueous chemistry and linker chemistry related to the synthesis of drug conjugates are all valued skills. Familiarity with hit triage, hit to lead campaigns from other discovery platforms, and an understanding of the physicochemical properties that drive drug discovery are desired.
As a member of a dynamic multi-disciplinary project team, this person will collaborate with a broad group of scientists within Nurix as well as with external collaborators.
PhD in synthetic organic chemistry with 0-8 years industrial chemistry experience (years of relevant experience will impact level of hire).
Expert in synthetic organic chemistry methods and analytical tools, in particular LCMS
High level of creativity and productivity with strong synthetic problem-solving skills.
Solid track record of scientific accomplishment demonstrated by publications, patents, or presentations
Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the department.
Familiarity with principles of combinatorial chemistry and DNA encoded library technology
Interest in optimizing chemical reactions for use in DNA encoded library synthesis.
Experience with chemistry involving biological macromolecules, i.e. antibodies and oligonucleotides, linker technologies, or the design and synthesis of chemical biology probes a plus.
Familiarity with working with large data sets and the tools necessary to effectively organize, visualize and distill data to facilitate rapid decision making.
Fit with Nurix Culture and Values
Strong team orientation; highly collaborative
Solutions and results-oriented focus
Hands-on approach; resourceful and open to diverse points of view
Internal Number: 1
About Nurix Therapeutics
Nurix discovers drugs that harness the body’s natural process to control protein levels. Dysregulated or mutated proteins are at the core of nearly every human disease. Novel therapies that control protein levels provide an opportunity for a new therapeutic approach to alter the development and progression of a broad range of diseases.
Nurix discovers and develops small molecule drugs that control E3 ubiquitin ligases, the key enzymes responsible for protein breakdown in human cells. Our initial focus is on a unique modality that manipulates protein breakdown for new treatments of hematologic cancers, immune-mediated diseases and in applications in immuno-oncology.
In September 2015, Nurix entered into a major collaboration with Celgene for the discovery and development of next-generation therapies targeting E3 ubiquitin ligases in oncology, immunology, and inflammation.
Nurix was founded by a team of experts in E3 ubiquitin ligase regulation and structure. The Nurix management team has extensive experience in biopharmaceutical drug development and is building an innovative biotechnology company around these exciting approaches to create new medicines to improve the li...ves of patients. The company is funded by leading life science investors Third Rock Ventures and The Column Group, and is headquartered in San Francisco’s biotechnology hub, Mission Bay.