Position is in the Department of Medicine, Division of Hematology, Oncology and Transplantation.
Our goal is to identify the molecular pathways required for self-renewal in a murine model and in primary human AML samples.
Seeking a postdoctoral associate to investigate the molecular pathways required for self-renewal in a murine model of AML and in primary human AML samples. Our lab focuses on unraveling the signaling and gene expression patterns at the single-cell level using whole transcriptome single-cell RNA sequencing and high dimensional mass cytometry (CyTOF, Fluidigm). The ideal candidate is a motivated scientist with training in the field of cancer biology or immunology, experience with flow cytometry and animal models, and an interest in using large-scale datasets to address biological questions.
40% Design and conduct experiments, supervise junior scientist and undergraduate students. Maintain excellent, detailed documentation in real-time (at least daily) 30% Analyze and interpret data, prepare figures for manuscripts and presentations, maintain expertise in the relevant literature. Communicate and meet with collaborators 20% Write manuscripts, progress reports, abstracts, assist with grant-writing, meet with PI 5% Present data at lab meetings, local and international conferences 5% Assist Junior scientist in laboratory management, inventory, ordering, organization, and other miscellaneous lab duties.
1. A PhD, MD or equivalent degree with extensive research training in the biological sciences 2. Proficiency in basic biology laboratory skills 3. Mouse handling experience OR willingness to handle mice and perform experiments on live mice
1. Proficiency in flow cytometry including data analysis 2. Interest in using bioinformatic tools for the analysis of high-parameter datasets 3. Proficiency or willingness to learn to handle live mice, including eye bleeds, intraperitoneal injections, tail-vein injections, and ear punching 4. Experience with sterile conditions (such as in tissue culture) 5. Molecular biology techniques including high quality RNA and DNA isolation and handling for next generation sequencing applications Quantitative PCR including primer design, experimental set-up, and data analysis. Protein isolation and immunoblotting
Internal Number: 320772
About University of Minnesota, Twin Cities
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